COMMD1 Antibody (PACO44492)
- SKU:
- PACO44492
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Application:
- IP
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
抗体名: | COMMD1 Antibody (PACO44492) |
抗体コード: | PACO44492 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC, IP |
推奨される希釈: | ELISA:1:2000-1:10000, WB:1:1000-1:5000, IHC:1:20-1:200, IP:1:200-1:2000 |
反応性: | Human |
免疫原: | Recombinant Human COMM domain-containing protein 1 protein (1-190AA) |
憲法: | Liquid |
ストレージバッファ: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
精製方法: | Antigen Affinity Purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
![]() | Western blot. All lanes: COMMD1 antibody at 5.36µg/ml. Lane 1: A549 whole cell lysate. Lane 2: Jurkat whole cell lysate. Lane 3: MCF-7 whole cell lysate. Lane 4: Hela whole cell lysate. Lane 5: HepG2 whole cell lysate. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 22, 18 kDa. Observed band size: 22 kDa.. |
![]() | Immunohistochemistry of paraffin-embedded human adrenal gland tissue using PACO44492 at dilution of 1:100. |
![]() | Immunohistochemistry of paraffin-embedded human liver cancer using PACO44492 at dilution of 1:100. |
バックグラウンド: | Proposed scaffold protein that is implicated in diverse physiological processes and whose function may be in part linked to its ability to regulate ubiquitination of specific cellular proteins. Can modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes by displacing CAND1; in vitro promotes CRL E3 activity and dissociates CAND1 from CUL1 and CUL2. Promotes ubiquitination of NF-kappa-B subunit RELA and its subsequent proteasomal degradation. Down-regulates NF-kappa-B activity. Involved in the regulation of membrane expression and ubiquitination of SLC12A2. Modulates Na(+) transport in epithelial cells by regulation of apical cell surface expression of amiloride-sensitive sodium channel (ENaC) subunits and by promoting their ubiquitination presumably involving NEDD4L. Promotes the localization of SCNN1D to recycling endosomes. Promotes CFTR cell surface expression through regulation of its ubiquitination. Down-regulates SOD1 activity by interfering with its homodimerization. Plays a role in copper ion homeostasis. Involved in copper-dependent ATP7A trafficking between the trans-Golgi network and vesicles in the cell periphery; the function is proposed to depend on its association within the CCC complex and cooperation with the WASH complex on early endosomes. Can bind one copper ion per monomer. May function to facilitate biliary copper excretion within hepatocytes. Binds to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Involved in the regulation of HIF1A-mediated transcription; competes with ARNT/Hif-1-β for binding to HIF1A resulting in decreased DNA binding and impaired transcriptional activation by HIF-1. |
シノニム: | COMM domain-containing protein 1 (Protein Murr1), COMMD1, C2orf5 MURR1 |
UniProt Protein Function: | COMMD1: Promotes ubiquitination of NF-kappa-B subunit RELA and its subsequent proteasomal degradation. Down-regulates NF-kappa-B activity. Down-regulates SOD1 activity by interfering with its homodimerization. Plays a role in copper ion homeostasis. Can bind one copper ion per monomer. May function to facilitate biliary copper excretion within hepatocytes. |
UniProt Protein Details: | Protein type:Inhibitor Chromosomal Location of Human Ortholog: 2p15 Cellular Component: Cul2-RING ubiquitin ligase complex; cytoplasm; cytoplasmic membrane-bound vesicle; early endosome; endosome membrane; nucleoplasm; nucleus; recycling endosome Molecular Function:copper ion binding; identical protein binding; phosphatidylinositol-3,4,5-triphosphate binding; phosphatidylinositol-3,4-bisphosphate binding; phosphatidylinositol-4,5-bisphosphate binding; protein binding; protein homodimerization activity Biological Process: copper ion homeostasis; Golgi to plasma membrane transport; inhibition of NF-kappaB transcription factor; plasma membrane to endosome transport; positive regulation of protein ubiquitination; protein transport; regulation of proteasomal ubiquitin-dependent protein catabolic process; transcription, DNA-dependent |
NCBI Summary: | COMMD1 is a regulator of copper homeostasis, sodium uptake, and NF-kappa-B (see MIM 164011) signaling (de Bie et al., 2005 [PubMed 16267171]).[supplied by OMIM, Sep 2009] |
UniProt Code: | Q8N668 |
NCBI GenInfo Identifier: | 51316026 |
NCBI Gene ID: | 150684 |
NCBI Accession: | Q8N668.1 |
UniProt Secondary Accession: | Q8N668,Q96GS0, B4DFQ4, |
UniProt Related Accession: | Q8N668 |
Molecular Weight: | 17,665 Da |
NCBI Full Name: | COMM domain-containing protein 1 |
NCBI Synonym Full Names: | copper metabolism domain containing 1 |
NCBI Official Symbol: | COMMD1 |
NCBI Official Synonym Symbols: | MURR1; C2orf5 |
NCBI Protein Information: | COMM domain-containing protein 1 |
UniProt Protein Name: | COMM domain-containing protein 1 |
UniProt Synonym Protein Names: | Protein Murr1 |
Protein Family: | COMM domain-containing protein |
UniProt Gene Name: | COMMD1 |
UniProt Entry Name: | COMD1_HUMAN |