COIL Antibody (PACO43974)
- SKU:
- PACO43974
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | COIL Antibody (PACO43974) |
抗体コード: | PACO43974 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC |
推奨される希釈: | ELISA:1:2000-1:10000, WB:1:200-1:1000, IHC:1:20-1:200 |
反応性: | Human |
免疫原: | Recombinant Human Coilin protein (297-576AA) |
憲法: | Liquid |
ストレージバッファ: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
精製方法: | Antigen Affinity Purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
![]() | Western blot. All lanes: COIL antibody at 3µg/ml. Lane 1: MCF-7 whole cell lysate. Lane 2: Hela whole cell lysate. Lane 3: HepG2 whole cell lysate. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 63 kDa. Observed band size: 63 kDa. |
![]() | Immunohistochemistry of paraffin-embedded human placenta tissue using PACO43974 at dilution of 1:100. |
バックグラウンド: | Component of nuclear coiled bodies, also known as Cajal bodies or CBs, which are involved in the modification and assembly of nucleoplasmic snRNPs. |
シノニム: | Coilin (p80-coilin), COIL, CLN80 |
UniProt Protein Function: | coilin: an ubiquitous protein found in nuclear coiled bodies (CBS), nuclear suborganelles involved in the post-transcriptional modification of snRNPs and small nucleolar RNAs. snRNPs undergo 2'-O-methylation and pseudouridylation in CBS. Differential methylation and phosphorylation of coilin likely influences localization among nuclear bodies and the composition and assembly of CBS. Located in the interchromatin space between the nucleolus and the nucleus. |
UniProt Protein Details: | Protein type:Oxidoreductase Chromosomal Location of Human Ortholog: 17q22 Cellular Component: nucleoplasm; Cajal body; membrane; cytoplasm; nucleolus; nucleus Molecular Function:protein C-terminus binding; identical protein binding; protein binding |
NCBI Summary: | The protein encoded by this gene is an integral component of Cajal bodies (also called coiled bodies). Cajal bodies are nuclear suborganelles of varying number and composition that are involved in the post-transcriptional modification of small nuclear and small nucleolar RNAs. The N-terminus of the coilin protein directs its self-oligomerization while the C-terminus influences the number of nuclear bodies assembled per cell. Differential methylation and phosphorylation of coilin likely influences its localization among nuclear bodies and the composition and assembly of Cajal bodies. This gene has pseudogenes on chromosome 4 and chromosome 14. [provided by RefSeq, Jul 2008] |
UniProt Code: | P38432 |
NCBI GenInfo Identifier: | 585632 |
NCBI Gene ID: | 8161 |
NCBI Accession: | P38432.1 |
UniProt Secondary Accession: | P38432,B2R931, |
UniProt Related Accession: | P38432 |
Molecular Weight: | 576 |
NCBI Full Name: | Coilin |
NCBI Synonym Full Names: | coilin |
NCBI Official Symbol: | COIL |
NCBI Official Synonym Symbols: | CLN80; p80-coilin |
NCBI Protein Information: | coilin; p80; coilin p80 |
UniProt Protein Name: | Coilin |
UniProt Synonym Protein Names: | p80-coilin |
Protein Family: | Coilin |
UniProt Gene Name: | COIL |
UniProt Entry Name: | COIL_HUMAN |