CNTN1 Antibody (PACO56466)
- SKU:
- PACO56466
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | CNTN1 Antibody (PACO56466) |
抗体コード: | PACO56466 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, IF |
推奨される希釈: | ELISA:1:2000-1:10000, IF:1:50-1:200 |
反応性: | Human |
免疫原: | Recombinant Human Contactin-1 protein (686-866AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
![]() | Immunofluorescence staining of A549 cells with PACO56466 at 1:66, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
バックグラウンド: | Contactins mediate cell surface interactions during nervous system development. Involved in the formation of paranodal axo-glial junctions in myelinated peripheral nerves and in the signaling between axons and myelinating glial cells via its association with CNTNAP1. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Interaction with TNR induces a repulsion of neurons and an inhibition of neurite outgrowth (By similarity). |
シノニム: | Contactin-1 (Glycoprotein gp135) (Neural cell surface protein F3), CNTN1 |
UniProt Protein Function: | CNTN1: Contactins mediate cell surface interactions during nervous system development. Involved in the formation of paranodal axo-glial junctions in myelinated peripheral nerves and in the signaling between axons and myelinating glial cells via its association with CNTNAP1. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Interaction with TNR induces a repulsion of neurons and an inhibition of neurite outgrowth. Defects in CNTN1 are the cause of Compton-North congenital myopathy (CNCM). CNCM is a familial lethal form of congenital onset muscle weakness, inherited in an autosomal-recessive fashion and characterized by a secondary loss of beta2-syntrophin and alpha-dystrobrevin from the muscle sarcolemma, central nervous system involvement, and fetal akinesia. Belongs to the immunoglobulin superfamily. Contactin family. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Cell adhesion; Membrane protein, GPI anchor Chromosomal Location of Human Ortholog: 12q11-q12 Cellular Component: membrane Disease: Myopathy, Congenital, Compton-north |
NCBI Summary: | The protein encoded by this gene is a member of the immunoglobulin superfamily. It is a glycosylphosphatidylinositol (GPI)-anchored neuronal membrane protein that functions as a cell adhesion molecule. It may play a role in the formation of axon connections in the developing nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011] |
UniProt Code: | Q12860 |
NCBI GenInfo Identifier: | 2497301 |
NCBI Gene ID: | 1272 |
NCBI Accession: | Q12860.1 |
UniProt Secondary Accession: | Q12860,Q12861, Q14030, Q7M4P0, Q8N466, A8K0H9, A8K0Y3 |
UniProt Related Accession: | Q12860 |
Molecular Weight: | 70,604 Da |
NCBI Full Name: | Contactin-1 |
NCBI Synonym Full Names: | contactin 1 |
NCBI Official Symbol: | CNTN1 |
NCBI Official Synonym Symbols: | F3; GP135; MYPCN |
NCBI Protein Information: | contactin-1 |
UniProt Protein Name: | Contactin-1 |
UniProt Synonym Protein Names: | Glycoprotein gp135; Neural cell surface protein F3 |
Protein Family: | Contactin |
UniProt Gene Name: | CNTN1 |
UniProt Entry Name: | CNTN1_HUMAN |
Antibodies | ELISA Kits |
Anti-CNTN1 Antibody (CAB17459) | Human CNTN1 / Contactin 1 ELISA Kit |
CNTN1 Antibody (PACO01836) | Human CNTN1 (Contactin 1) CLIA Kit (HUES00853) |
Human Contactin-1 (CNTN1) ELISA Kit |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |