CNOT8 Antibody (PACO43142)
- SKU:
- PACO43142
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | CNOT8 Antibody (PACO43142) |
抗体コード: | PACO43142 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, IHC |
推奨される希釈: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
反応性: | Human |
免疫原: | Recombinant Human CCR4-NOT transcription complex subunit 8 protein (1-292AA) |
憲法: | Liquid |
ストレージバッファ: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
精製方法: | Antigen Affinity Purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
![]() | Immunohistochemistry of paraffin-embedded human prostate cancer using PACO43142 at dilution of 1:100. |
![]() | Immunohistochemistry of paraffin-embedded human colon cancer using PACO43142 at dilution of 1:100. |
バックグラウンド: | Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT7. Catalytic component of the CCR4-NOT complex which is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be a consequence of its influence on mRNA expression. Associates with members of the BTG family such as TOB1 and BTG2 and is required for their anti-proliferative activity. |
シノニム: | CCR4-NOT transcription complex subunit 8 (EC 3.1.13.4) (CAF1-like protein) (CALIFp) (CAF2) (CCR4-associated factor 8) (Caf1b), CNOT8, CALIF POP2 |
UniProt Protein Function: | CNOT8: Ubiquitous transcription factor required for a diverse set of processes. The CCR4-NOT complex functions as general transcription regulation complex. Belongs to the CAF1 family. |
UniProt Protein Details: | Protein type:EC 3.1.13.4 Chromosomal Location of Human Ortholog: 5q31-q33 Cellular Component: intracellular; cytosol; nucleus; CCR4-NOT complex Molecular Function:protein binding; 3'-5'-exoribonuclease activity; poly(A)-specific ribonuclease activity; RNA binding; metal ion binding; transcription factor activity Biological Process: regulation of translation; negative regulation of cell proliferation; poly(A) tail shortening; transcription, DNA-dependent; regulation of transcription, DNA-dependent; positive regulation of cell proliferation; gene expression; miRNA-mediated gene silencing; mRNA catabolic process, deadenylation-dependent decay |
UniProt Code: | Q9UFF9 |
NCBI GenInfo Identifier: | 15213949 |
NCBI Gene ID: | 9337 |
NCBI Accession: | Q9UFF9.1 |
UniProt Secondary Accession: | Q9UFF9,O95709, Q7Z521, Q9H6Y1, B0AZS3, B2RAR8, B7Z8R1 D3DQI8, |
UniProt Related Accession: | Q9UFF9 |
Molecular Weight: | 27,415 Da |
NCBI Full Name: | CCR4-NOT transcription complex subunit 8 |
NCBI Synonym Full Names: | CCR4-NOT transcription complex, subunit 8 |
NCBI Official Symbol: | CNOT8 |
NCBI Official Synonym Symbols: | CAF1; POP2; CALIF; Caf1b; hCAF1 |
NCBI Protein Information: | CCR4-NOT transcription complex subunit 8; CAF2; CALIFp; CAF1-like protein; CCR4-associated factor 8; PGK promoter directed over production |
UniProt Protein Name: | CCR4-NOT transcription complex subunit 8 |
UniProt Synonym Protein Names: | CAF1-like protein; CALIFp; CAF2; CCR4-associated factor 8; Caf1b |
Protein Family: | CCR4-NOT transcription complex |
UniProt Gene Name: | CNOT8 |
UniProt Entry Name: | CNOT8_HUMAN |