CNOT1 Antibody, HRP conjugated (PACO45751)
- SKU:
- PACO45751
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- HRP
Description
抗体名: | CNOT1 Antibody, HRP conjugated (PACO45751) |
抗体コード: | PACO45751 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human CCR4-NOT transcription complex subunit 1 protein (604-867AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | HRP |
バックグラウンド: | Scaffolding component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Its scaffolding function implies its interaction with the catalytic complex module and diverse RNA-binding proteins mediating the complex recruitment to selected mRNA 3'UTRs. Involved in degradation of AU-rich element (ARE)-containing mRNAs probably via association with ZFP36. Mediates the recruitment of the CCR4-NOT complex to miRNA targets and to the RISC complex via association with TNRC6A, TNRC6B or TNRC6C. Acts as a transcriptional repressor. Represses the ligand-dependent transcriptional activation by nuclear receptors. Involved in the maintenance of emryonic stem (ES) cell identity. |
シノニム: | CCR4-NOT transcription complex subunit 1 (CCR4-associated factor 1) (Negative regulator of transcription subunit 1 homolog) (NOT1H) (hNOT1), CNOT1, CDC39 KIAA1007 NOT1 |
UniProt Protein Function: | NOT1: represses ligand-dependent transcriptional activation by oestrogen receptor (ER) alpha and several RXR heterodimers. Interacts with the ligand-binding domain of estrogen receptor-alpha in a hormone-dependent fashion. |
UniProt Protein Details: | Protein type:Nuclear receptor co-regulator; Transcription, coactivator/corepressor; RNA-binding Chromosomal Location of Human Ortholog: 16q21 Cellular Component: nucleoplasm; peroxisomal membrane; extracellular space; membrane; cytosol; CCR4-NOT complex Molecular Function:protein domain specific binding; protein binding; poly(A)-specific ribonuclease activity; retinoic acid receptor binding; estrogen receptor binding; protein complex scaffold Biological Process: poly(A) tail shortening; negative regulation of retinoic acid receptor signaling pathway; transcription, DNA-dependent; negative regulation of translation; multicellular organismal development; gene expression; negative regulation of transcription from RNA polymerase II promoter; miRNA-mediated gene silencing; negative regulation of estrogen receptor signaling pathway; mRNA catabolic process, deadenylation-dependent decay |
UniProt Code: | A5YKK6 |
NCBI GenInfo Identifier: | 166216086 |
NCBI Gene ID: | 23019 |
NCBI Accession: | A5YKK6.2 |
UniProt Secondary Accession: | A5YKK6,Q68DX7, Q7Z3K2, Q8IWB8, Q8TB53, Q9BVZ6, Q9UFR8 Q9UI27, Q9Y2L0, |
UniProt Related Accession: | A5YKK6 |
Molecular Weight: | 2376 |
NCBI Full Name: | CCR4-NOT transcription complex subunit 1 |
NCBI Synonym Full Names: | CCR4-NOT transcription complex, subunit 1 |
NCBI Official Symbol: | CNOT1 |
NCBI Official Synonym Symbols: | NOT1; CDC39; NOT1H; AD-005 |
NCBI Protein Information: | CCR4-NOT transcription complex subunit 1; CCR4-associated factor 1; adrenal gland protein AD-005; negative regulator of transcription subunit 1 homolog; NOT1 (negative regulator of transcription 1, yeast) homolog |
UniProt Protein Name: | CCR4-NOT transcription complex subunit 1 |
UniProt Synonym Protein Names: | CCR4-associated factor 1; Negative regulator of transcription subunit 1 homolog; NOT1H; hNOT1 |
Protein Family: | CCR4-NOT transcription complex |
UniProt Gene Name: | CNOT1 |
UniProt Entry Name: | CNOT1_HUMAN |