CNGA4 Antibody, Biotin conjugated (PACO37601)
- SKU:
- PACO37601
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- Biotin
Frequently bought together:
Description
抗体名: | CNGA4 Antibody, Biotin conjugated (PACO37601) |
抗体コード: | PACO37601 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Cyclic nucleotide-gated cation channel alpha-4 protein (1-575AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Biotin |
バックグラウンド: | Second messenger, cAMP, causes the opening of cation-selective cyclic nucleotide-gated (CNG) channels and depolarization of the neuron (olfactory sensory neurons, OSNs). CNGA4 is the modulatory subunit of this channel which is known to play a central role in the transduction of odorant signals and subsequent adaptation. By accelerating the calcium-mediated negative feedback in olfactory signaling it allows rapid adaptation to odor stimulation and extends its range of odor detection. |
シノニム: | Cyclic nucleotide-gated cation channel alpha-4 (Cyclic nucleotide-gated channel alpha-4) (CNG channel alpha-4) (CNG-4) (CNG4), CNGA4 |
UniProt Protein Function: | CNGA4: Second messenger, cAMP, causes the opening of cation- selective cyclic nucleotide-gated (CNG) channels and depolarization of the neuron (olfactory sensory neurons, OSNs). CNGA4 is the modulatory subunit of this channel which is known to play a central role in the transduction of odorant signals and subsequent adaptation. By accelerating the calcium-mediated negative feedback in olfactory signaling it allows rapid adaptation to odor stimulation and extends its range of odor detection. Belongs to the cyclic nucleotide-gated cation channel (TC 1.A.1.5) family. CNGA4 subfamily. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Membrane protein, integral; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 11p15.4 Cellular Component: Golgi membrane; integral to plasma membrane Molecular Function:cGMP binding; intracellular cAMP activated cation channel activity; intracellular cGMP activated cation channel activity; voltage-gated potassium channel activity Biological Process: regulation of membrane potential |
NCBI Summary: | CNGA4 is a modulatory subunit of vertebrate cyclic nucleotide-gated membrane channels that transduce odorant signals (Munger et al., 2001 [PubMed 11739959]).[supplied by OMIM, Mar 2008] |
UniProt Code: | Q8IV77 |
NCBI GenInfo Identifier: | 311033466 |
NCBI Gene ID: | 1262 |
NCBI Accession: | Q8IV77.3 |
UniProt Related Accession: | Q8IV77 |
Molecular Weight: | 47,743 Da |
NCBI Full Name: | Cyclic nucleotide-gated cation channel alpha-4 |
NCBI Synonym Full Names: | cyclic nucleotide gated channel alpha 4 |
NCBI Official Symbol: | CNGA4 |
NCBI Official Synonym Symbols: | CNG4; CNG5; CNCA2; CNG-4; CNGB2; OCNC2; OCNCb; OCNCBETA |
NCBI Protein Information: | cyclic nucleotide-gated cation channel alpha-4 |
UniProt Protein Name: | Cyclic nucleotide-gated cation channel alpha-4 |
UniProt Synonym Protein Names: | Cyclic nucleotide-gated channel alpha-4; CNG channel alpha-4; CNG-4; CNG4 |
Protein Family: | Cyclic nucleotide-gated cation channel |
UniProt Gene Name: | CNGA4 |
UniProt Entry Name: | CNGA4_HUMAN |