CMKLR1 Antibody (PACO54714)
- SKU:
- PACO54714
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | CMKLR1 Antibody (PACO54714) |
抗体コード: | PACO54714 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, IHC, IF |
推奨される希釈: | ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:50-1:200 |
反応性: | Human |
免疫原: | Recombinant Human Chemokine-like receptor 1 protein (321-373AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
![]() | Immunohistochemistry of paraffin-embedded human kidney tissue using PACO54714 at dilution of 1:100. |
![]() | Immunofluorescence staining of HepG2 cells with PACO54714 at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
![]() | Immunohistochemistry of paraffin-embedded human breast cancer using PACO54714 at dilution of 1:100. |
バックグラウンド: | Receptor for the chemoattractant adipokine chemerin/RARRES2 and for the omega-3 fatty acid, derived molecule resolvin E1. Interaction with RARRES2 induces activation of intracellular signaling molecules, such as SKY, MAPK1/3 (ERK1/2), MAPK14/P38MAPK and PI3K leading to multifunctional effects, like, reduction of immune responses, enhancing of adipogenesis and angionesis. Resolvin E1 down-regulates cytokine production in macrophages by reducing the activation of MAPK1/3 (ERK1/2) and NF-kappa-B. Positively regulates adipogenesis and adipocyte metabolism. Acts as a coreceptor for several SIV strains (SIVMAC316, SIVMAC239, SIVMACL7E-FR and SIVSM62A), as well as a primary HIV-1 strain (92UG024-2). |
シノニム: | Chemokine-like receptor 1 (G-protein coupled receptor ChemR23) (G-protein coupled receptor DEZ), CMKLR1, CHEMR23 DEZ |
UniProt Protein Function: | CMKLR1: Receptor for the chemoattractant adipokine chemerin/RARRES2 and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with RARRES2 induces activation of intracellular signaling molecules, such as SKY, MAPK1/3 (ERK1/2), MAPK14/P38MAPK and PI3K leading to multifunctional effects, like, reduction of immune responses, enhancing of adipogenesis and angionesis. Resolvin E1 down-regulates cytokine production in macrophages by reducing the activation of MAPK1/3 (ERK1/2) and NF- kappa-B. Acts as a coreceptor for several SIV strains (SIVMAC316, SIVMAC239, SIVMACL7E-FR and SIVSM62A), as well as a primary HIV-1 strain (92UG024-2). Belongs to the G-protein coupled receptor 1 family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Membrane protein, multi-pass; Receptor, GPCR; Membrane protein, integral; GPCR, family 1 Chromosomal Location of Human Ortholog: 12q24.1 Cellular Component: integral to plasma membrane; plasma membrane; integral to membrane Molecular Function:G-protein coupled receptor activity; protein binding; chemokine receptor activity; receptor activity Biological Process: G-protein coupled receptor protein signaling pathway; negative regulation of interleukin-12 production; inhibition of NF-kappaB transcription factor; regulation of calcium-mediated signaling; positive regulation of fat cell differentiation; immune response; chemotaxis; skeletal development |
UniProt Code: | Q99788 |
NCBI GenInfo Identifier: | 17380487 |
NCBI Gene ID: | 1240 |
NCBI Accession: | Q99788.2 |
UniProt Secondary Accession: | Q99788,O75748, Q3KP37, Q5U0H0, Q99789, A8K6Y5, |
UniProt Related Accession: | Q99788 |
Molecular Weight: | 42,035 Da |
NCBI Full Name: | Chemokine-like receptor 1 |
NCBI Synonym Full Names: | chemokine-like receptor 1 |
NCBI Official Symbol: | CMKLR1 |
NCBI Official Synonym Symbols: | DEZ; RVER1; ChemR23; CHEMERINR |
NCBI Protein Information: | chemokine-like receptor 1; chemerin receptor; resolvin E1 receptor; chemokine receptor-like 1; G-protein coupled receptor DEZ; G-protein coupled receptor ChemR23; orphan G-protein coupled receptor, Dez |
UniProt Protein Name: | Chemokine-like receptor 1 |
UniProt Synonym Protein Names: | G-protein coupled receptor ChemR23; G-protein coupled receptor DEZ |
UniProt Gene Name: | CMKLR1 |
UniProt Entry Name: | CML1_HUMAN |