CLPS Antibody, FITC conjugated (PACO57710)
- SKU:
- PACO57710
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- FITC
Frequently bought together:
Description
抗体名: | CLPS Antibody, FITC conjugated (PACO57710) |
抗体コード: | PACO57710 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Colipase protein (23-112AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | FITC |
バックグラウンド: | Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase. |
シノニム: | Colipase, CLPS |
UniProt Protein Function: | CLPS: Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase. Belongs to the colipase family. |
UniProt Protein Details: | Protein type:Activator; Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: 6p21.31 Cellular Component: extracellular region Molecular Function:enzyme activator activity Biological Process: positive regulation of catalytic activity; phototransduction, visible light; lipid metabolic process; retinoid metabolic process; lipid catabolic process; lipid digestion |
NCBI Summary: | The protein encoded by this gene is a cofactor needed by pancreatic lipase for efficient dietary lipid hydrolysis. It binds to the C-terminal, non-catalytic domain of lipase, thereby stabilizing an active conformation and considerably increasing the overall hydrophobic binding site. The gene product allows lipase to anchor noncovalently to the surface of lipid micelles, counteracting the destabilizing influence of intestinal bile salts. This cofactor is only expressed in pancreatic acinar cells, suggesting regulation of expression by tissue-specific elements. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011] |
UniProt Code: | P04118 |
NCBI GenInfo Identifier: | 116900 |
NCBI Gene ID: | 1208 |
NCBI Accession: | P04118.2 |
UniProt Secondary Accession: | P04118,Q5T9G7, Q5U809, |
UniProt Related Accession: | P04118 |
Molecular Weight: | 112 |
NCBI Full Name: | Colipase |
NCBI Synonym Full Names: | colipase, pancreatic |
NCBI Official Symbol: | CLPS |
NCBI Protein Information: | colipase; pancreatic colipase preproprotein |
UniProt Protein Name: | Colipase |
Protein Family: | Colipase |
UniProt Gene Name: | CLPS |
UniProt Entry Name: | COL_HUMAN |