CLEC4C Antibody, FITC conjugated (PACO39996)
- SKU:
- PACO39996
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- FITC
Frequently bought together:
Description
抗体名: | CLEC4C Antibody, FITC conjugated (PACO39996) |
抗体コード: | PACO39996 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human C-type lectin domain family 4 member C protein (45-213AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | FITC |
バックグラウンド: | Involved in antigen-capturing. Target ligand into antigen processing and peptide-loading compartments for presentation to T-cells. May mediate potent inhibition of induction of IFN-alpha/β expression in plasmacytoid dendritic cells. May act as a signaling receptor that activates protein-tyrosine kinases and mobilizes intracellular calcium. Does not seem to bind mannose. |
シノニム: | C-type lectin domain family 4 member C (Blood dendritic cell antigen 2) (BDCA-2) (C-type lectin superfamily member 7) (Dendritic lectin) (CD antigen CD303), CLEC4C, BDCA2 CLECSF11 CLECSF7 DLEC HECL |
UniProt Protein Function: | NRTN: Supports the survival of sympathetic neurons in culture. May regulate the development and maintenance of the CNS. Might control the size of non-neuronal cell population such as haemopoietic cells. Genetic variations in NRTN may contribute to Hirschsprung disease, in association with mutations of RET gene, and possibly mutations in other loci. Hirschsprung disease is a disorder of neural crest development is characterized by the absence of intramural ganglion cells in the hindgut, often resulting in intestinal obstruction. Belongs to the TGF-beta family. GDNF subfamily. |
UniProt Protein Details: | Protein type:Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: 19p13.3 Cellular Component: axon; extracellular region Molecular Function:growth factor activity; receptor binding Biological Process: nervous system development; axon guidance; MAPKKK cascade; nerve development; neural crest cell migration; neurite development; transmembrane receptor protein tyrosine kinase signaling pathway Disease: Hirschsprung Disease, Susceptibility To, 1 |
NCBI Summary: | This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type 2 transmembrane protein may play a role in dendritic cell function. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q8WTT0 |
NCBI GenInfo Identifier: | 18466806 |
NCBI Gene ID: | 170482 |
NCBI Accession: | NP_569708 |
UniProt Related Accession: | Q8WTT0 |
Molecular Weight: | |
NCBI Full Name: | C-type lectin domain family 4 member C isoform 1 |
NCBI Synonym Full Names: | C-type lectin domain family 4 member C |
NCBI Official Symbol: | CLEC4C |
NCBI Official Synonym Symbols: | DLEC; HECL; BDCA2; CD303; BDCA-2; CLECSF7; CLECSF11; PRO34150 |
NCBI Protein Information: | C-type lectin domain family 4 member C |
UniProt Protein Name: | Neurturin |
Protein Family: | Neurturin |
UniProt Gene Name: | NRTN |
UniProt Entry Name: | NRTN_HUMAN |