UniProt Protein Function: | CLEC4A: May be involved in regulating immune reactivity. May play a role in modulating dendritic cells (DC) differentiation and/or maturation. May be involved via its ITIM motif (immunoreceptor tyrosine-based inhibitory motifs) in the inhibition of B-cell-receptor-mediated calcium mobilization and protein tyrosine phosphorylation. 4 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Membrane protein, integral; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 12p13 Cellular Component: integral to plasma membrane Molecular Function:transmembrane receptor activity; carbohydrate binding Biological Process: cell surface receptor linked signal transduction; innate immune response; cell adhesion |
NCBI Summary: | This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type 2 transmembrane protein may play a role in inflammatory and immune response. Multiple transcript variants encoding distinct isoforms have been identified for this gene. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q9UMR7 |
NCBI GenInfo Identifier: | 59797977 |
NCBI Gene ID: | 50856 |
NCBI Accession: | Q9UMR7.1 |
UniProt Secondary Accession: | Q9UMR7,Q17R69, Q8WXW9, Q9H2Z9, Q9NS33, Q9UI34, |
UniProt Related Accession: | Q9UMR7 |
Molecular Weight: | 237 |
NCBI Full Name: | C-type lectin domain family 4 member A |
NCBI Synonym Full Names: | C-type lectin domain family 4, member A |
NCBI Official Symbol: | CLEC4A |
NCBI Official Synonym Symbols: | DCIR; LLIR; DDB27; CLECSF6; HDCGC13P |
NCBI Protein Information: | C-type lectin domain family 4 member A; C-type lectin DDB27; lectin-like immunoreceptor; dendritic cell immunoreceptor; C-type lectin superfamily member 6; C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 6 |
UniProt Protein Name: | C-type lectin domain family 4 member A |
UniProt Synonym Protein Names: | C-type lectin DDB27; C-type lectin superfamily member 6; Dendritic cell immunoreceptor; Lectin-like immunoreceptor |
UniProt Gene Name: | CLEC4A |
UniProt Entry Name: | CLC4A_HUMAN |