CLDN19 Antibody (PACO17715)
- SKU:
- PACO17715
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | CLDN19 Antibody (PACO17715) |
抗体コード: | PACO17715 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC |
推奨される希釈: | ELISA:1:1000-1:2000, WB:1:200-1:1000, IHC:1:10-1:50 |
反応性: | Human, Mouse, Rat |
免疫原: | Synthetic peptide of human CLDN19 |
憲法: | Liquid |
ストレージバッファ: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
精製方法: | Antigen affinity purification |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
![]() | Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Hepg2 and 293T cell, Primary antibody: PACO17715(CLDN19 Antibody) at dilution 1/200 dilution, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 seconds. |
![]() | The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO17715(CLDN19 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200). |
バックグラウンド: | The product of this gene belongs to the claudin family. It plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. Defects in this gene are the cause of hypomagnesemia renal with ocular involvement (HOMGO). HOMGO is a progressive renal disease characterized by primary renal magnesium wasting with hypomagnesemia, hypercalciuria and nephrocalcinosis associated with severe ocular abnormalities such as bilateral chorioretinal scars, macular colobomata, significant myopia and nystagmus. |
シノニム: | claudin 19 |
UniProt Protein Function: | Claudin-19: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity. Defects in CLDN19 are the cause of hypomagnesemia renal with ocular involvement (HOMG5). HOMG5 is a progressive renal disease characterized by primary renal magnesium wasting with hypomagnesemia, hypercalciuria and nephrocalcinosis associated with severe ocular abnormalities such as bilateral chorioretinal scars, macular colobomata, significant myopia and nystagmus. The renal phenotype is virtually undistinguishable from that of patients with HOMG3 with proven CLDN16 mutations. Belongs to the claudin family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Membrane protein, integral; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 1p34.2 Cellular Component: apical junction complex; tight junction; basolateral plasma membrane; cytoplasm; integral to membrane; nucleus Molecular Function:identical protein binding; structural molecule activity Biological Process: apical junction assembly; visual perception; response to stimulus; action potential propagation; calcium-independent cell-cell adhesion Disease: Hypomagnesemia 5, Renal, With Ocular Involvement |
NCBI Summary: | The product of this gene belongs to the claudin family. It plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. Defects in this gene are the cause of hypomagnesemia renal with ocular involvement (HOMGO). HOMGO is a progressive renal disease characterized by primary renal magnesium wasting with hypomagnesemia, hypercalciuria and nephrocalcinosis associated with severe ocular abnormalities such as bilateral chorioretinal scars, macular colobomata, significant myopia and nystagmus. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jun 2010] |
UniProt Code: | Q8N6F1 |
NCBI GenInfo Identifier: | 47606757 |
NCBI Gene ID: | 149461 |
NCBI Accession: | Q8N6F1.2 |
UniProt Secondary Accession: | Q8N6F1,Q5QT57, Q8N8X0, B7Z5I2, F5H5P9, |
UniProt Related Accession: | Q8N6F1 |
Molecular Weight: | 224 |
NCBI Full Name: | Claudin-19 |
NCBI Synonym Full Names: | claudin 19 |
NCBI Official Symbol: | CLDN19 |
NCBI Official Synonym Symbols: | HOMG5 |
NCBI Protein Information: | claudin-19 |
UniProt Protein Name: | Claudin-19 |
Protein Family: | Claudin |
UniProt Gene Name: | CLDN19 |
UniProt Entry Name: | CLD19_HUMAN |