UniProt Protein Function: | nAChRB3: After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Beta- 3/CHRNB3 sub-subfamily. |
UniProt Protein Details: | Protein type:Channel, cation; Membrane protein, integral; Membrane protein, multi-pass; Channel, ligand-gated Chromosomal Location of Human Ortholog: 8p11.2 Cellular Component: plasma membrane Molecular Function:acetylcholine binding; acetylcholine receptor activity; channel activity; ligand-gated ion channel activity Biological Process: neuromuscular synaptic transmission; response to nicotine; signal transduction; synaptic transmission, cholinergic; transport |
NCBI Summary: | The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The nAChRs are (hetero)pentamers composed of homologous subunits. The subunits that make up the muscle and neuronal forms of nAChRs are encoded by separate genes and have different primary structure. There are several subtypes of neuronal nAChRs that vary based on which homologous subunits are arranged around the central channel. They are classified as alpha-subunits if, like muscle alpha-1 (MIM 100690), they have a pair of adjacent cysteines as part of the presumed acetylcholine binding site. Subunits lacking these cysteine residues are classified as beta-subunits (Groot Kormelink and Luyten, 1997 [PubMed 9009220]). Elliott et al. (1996) [PubMed 8906617] stated that the proposed structure for each subunit is a conserved N-terminal extracellular domain followed by 3 conserved transmembrane domains, a variable cytoplasmic loop, a fourth conserved transmembrane domain, and a short C-terminal extracellular region.[supplied by OMIM, Apr 2010] |
UniProt Code: | Q05901 |
NCBI GenInfo Identifier: | 2506128 |
NCBI Gene ID: | 1142 |
NCBI Accession: | Q05901.2 |
UniProt Secondary Accession: | Q05901,Q15827, |
UniProt Related Accession: | Q05901 |
Molecular Weight: | 52,729 Da |
NCBI Full Name: | Neuronal acetylcholine receptor subunit beta-3 |
NCBI Synonym Full Names: | cholinergic receptor nicotinic beta 3 subunit |
NCBI Official Symbol: | CHRNB3 |
NCBI Protein Information: | neuronal acetylcholine receptor subunit beta-3 |
UniProt Protein Name: | Neuronal acetylcholine receptor subunit beta-3 |
Protein Family: | Neuronal acetylcholine receptor |
UniProt Gene Name: | CHRNB3 |
UniProt Entry Name: | ACHB3_HUMAN |