CHRM1 Antibody (PACO64007)
- SKU:
- PACO64007
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Muscarinic acetylcholine receptor M1
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
| 抗体名: | CHRM1 Antibody (PACO64007) |
| 抗体コード: | PACO64007 |
| サイズ: | 50ul |
| 宿主種: | Muscarinic acetylcholine receptor M1 |
| 申し込み: | ELISA, IF |
| 推奨される希釈: | ELISA:1:2000-1:10000, IF:1:50-1:200 |
| 反応性: | Human |
| 免疫原: | Peptide sequence from Human Muscarinic acetylcholine receptor M1 protein (2-21aa) |
| 憲法: | Liquid |
| ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| 精製方法: | >95%, Antigen Affinity purified & Affinity purified |
| 抗体のクローン性: | Polyclonal |
| アイソタイプ: | IgG |
| Conjugate: | Non-conjugated |
 | Immunofluorescence staining of U251 cells with PACO64007 at 1:50,counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C.The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG (H+L). |
| バックグラウンド: | The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover. |
| シノニム: | Muscarinic acetylcholine receptor M1, CHRM1 |
| UniProt Protein Function: | mAChR m1: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover. Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM1 sub-subfamily. |
| UniProt Protein Details: | Protein type:GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Chromosomal Location of Human Ortholog: 11q12.3 Cellular Component: membrane; plasma membrane; synapse Molecular Function:G-protein coupled acetylcholine receptor activity; phosphoinositide phospholipase C activity Biological Process: acetylcholine receptor signaling, muscarinic pathway; cell proliferation; G-protein coupled receptor protein signaling pathway; muscarinic acetylcholine receptor, adenylate cyclase inhibiting pathway; muscarinic acetylcholine receptor, phospholipase C activating pathway; nervous system development; positive regulation of cell proliferation; positive regulation of ion transport; protein kinase C activation; protein modification process; regulation of vascular smooth muscle contraction; signal transduction; synaptic transmission, cholinergic |
| NCBI Summary: | The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 1 is involved in mediation of vagally-induced bronchoconstriction and in the acid secretion of the gastrointestinal tract. The gene encoding this receptor is localized to 11q13. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P11229 |
| NCBI GenInfo Identifier: | 113118 |
| NCBI Gene ID: | 1128 |
| NCBI Accession: | P11229.2 |
| UniProt Secondary Accession: | P11229,Q96RH1, |
| UniProt Related Accession: | P11229 |
| Molecular Weight: | 51kDa |
| NCBI Full Name: | Muscarinic acetylcholine receptor M1 |
| NCBI Synonym Full Names: | cholinergic receptor muscarinic 1 |
| NCBI Official Symbol: | CHRM1 |
| NCBI Official Synonym Symbols: | M1; HM1; M1R |
| NCBI Protein Information: | muscarinic acetylcholine receptor M1 |
| UniProt Protein Name: | Muscarinic acetylcholine receptor M1 |
| Protein Family: | Muscarinic acetylcholine receptor |
| UniProt Gene Name: | CHRM1 |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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