Cfb Antibody, Biotin conjugated (PACO53641)
- SKU:
- PACO53641
- Product type:
- Antibody
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- Biotin
Frequently bought together:
Description
抗体名: | Cfb Antibody, Biotin conjugated (PACO53641) |
抗体コード: | PACO53641 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Mouse |
免疫原: | Recombinant Mouse Complement factor B protein (23-761AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Biotin |
バックグラウンド: | Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments: Ba and Bb. Bb, a serine protease, then combines with complement factor 3b to generate the C3 or C5 convertase. It has also been implicated in proliferation and differentiation of preactivated B-lymphocytes, rapid spreading of peripheral blood monocytes, stimulation of lymphocyte blastogenesis and lysis of erythrocytes. Ba inhibits the proliferation of preactivated B-lymphocytes. |
シノニム: | Complement factor B (EC 3.4.21.47) (C3/C5 convertase) [Cleaved into: Complement factor B Ba fragment; Complement factor B Bb fragment], Cfb, Bf H2-Bf |
UniProt Protein Function: | CFB: Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments: Ba and Bb. Bb, a serine protease, then combines with complement factor 3b to generate the C3 or C5 convertase. It has also been implicated in proliferation and differentiation of preactivated B- lymphocytes, rapid spreading of peripheral blood monocytes, stimulation of lymphocyte blastogenesis and lysis of erythrocytes. Ba inhibits the proliferation of preactivated B-lymphocytes. Defects in CFB are a cause of susceptibility to hemolytic uremic syndrome atypical type 4 (AHUS4). An atypical form of hemolytic uremic syndrome. It is a complex genetic disease characterized by microangiopathic hemolytic anemia, thrombocytopenia, renal failure and absence of episodes of enterocolitis and diarrhea. In contrast to typical hemolytic uremic syndrome, atypical forms have a poorer prognosis, with higher death rates and frequent progression to end-stage renal disease. Susceptibility to the development of atypical hemolytic uremic syndrome can be conferred by mutations in various components of or regulatory factors in the complement cascade system. Other genes may play a role in modifying the phenotype. Belongs to the peptidase S1 family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:EC 3.4.21.47; Protease; Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 17 B1|17 18.41 cM Cellular Component: blood microparticle; extracellular exosome; extracellular region; extracellular space Molecular Function:hydrolase activity; peptidase activity; serine-type endopeptidase activity; serine-type peptidase activity Biological Process: cell proliferation; complement activation; complement activation, alternative pathway; immune system process; innate immune response; proteolysis |
UniProt Code: | P04186 |
NCBI GenInfo Identifier: | 116126 |
NCBI Gene ID: | 14962 |
NCBI Accession: | P04186.2 |
UniProt Related Accession: | P04186 |
Molecular Weight: | |
NCBI Full Name: | Complement factor B |
NCBI Synonym Full Names: | complement factor B |
NCBI Official Symbol: | Cfb |
NCBI Official Synonym Symbols: | B; Bf; C2; Fb; H2-Bf; AI195813; AI255840 |
NCBI Protein Information: | complement factor B |
UniProt Protein Name: | Complement factor B |
UniProt Synonym Protein Names: | C3/C5 convertase |
Protein Family: | Complement factor |
UniProt Gene Name: | Cfb |