CERKL Antibody (PACO00589)
- SKU:
- PACO00589
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | CERKL Antibody |
抗体コード: | PACO00589 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC |
推奨される希釈: | WB:1:500-1:2000, IHC:1:100-1:300 |
反応性: | Human |
免疫原: | synthesized peptide derived from the Internal region of human CERKL. |
憲法: | Liquid |
ストレージバッファ: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
精製方法: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
シノニム: | CERKL; Ceramide kinase-like protein |
UniProt Protein Function: | CERKL: Has no detectable ceramide-kinase activity. Overexpression of CERKL protects cells from apoptosis in oxidative stress conditions. Defects in CERKL are the cause of retinitis pigmentosa type 26 (RP26). RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. RP26 inheritance is autosomal recessive. 8 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Nucleolus; Kinase, other Chromosomal Location of Human Ortholog: 2q31.3 Disease: Retinitis Pigmentosa 26 |
NCBI Summary: | This gene was initially identified as a locus (RP26) associated with an autosomal recessive form of retinitis pigmentosa (arRP) disease. This gene encodes a protein with ceramide kinase-like domains, however, the protein does not phosphorylate ceramide and its target substrate is currently unknown. This protein may be a negative regulator of apoptosis in photoreceptor cells. Mutations in this gene cause a form of retinitis pigmentosa characterized by autosomal recessive cone and rod dystrophy (arCRD). Alternative splicing of this gene results in multiple transcript variants encoding different isoforms and non-coding transcripts.[provided by RefSeq, May 2010] |
UniProt Code: | Q49MI3 |
NCBI GenInfo Identifier: | 84028814 |
NCBI Gene ID: | 375298 |
NCBI Accession: | Q49MI3.1 |
UniProt Secondary Accession: | Q49MI3,Q49MH9, Q49MI0, Q49MI1, Q49MI2, Q5DVJ2, Q5DVJ4 Q5DVJ5, Q6UZF6, Q6ZP59, B2RPL2, B4DEY1, |
UniProt Related Accession: | Q49MI3 |
Molecular Weight: | 57,632 Da |
NCBI Full Name: | Ceramide kinase-like protein |
NCBI Synonym Full Names: | ceramide kinase like |
NCBI Official Symbol: | CERKL |
NCBI Official Synonym Symbols: | RP26 |
NCBI Protein Information: | ceramide kinase-like protein |
UniProt Protein Name: | Ceramide kinase-like protein |
Protein Family: | Ceramide kinase-like protein |
UniProt Gene Name: | CERKL |
UniProt Entry Name: | CERKL_HUMAN |