CENPJ Antibody, Biotin conjugated (PACO57703)
- SKU:
- PACO57703
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- Biotin
Description
抗体名: | CENPJ Antibody, Biotin conjugated (PACO57703) |
抗体コード: | PACO57703 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Centromere protein J protein (1082-1248AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Biotin |
バックグラウンド: | Plays an important role in cell division and centrosome function by participating in centriole duplication. Inhibits microtubule nucleation from the centrosome. Involved in the regulation of slow processive growth of centriolar microtubules. Acts as microtubule plus-end tracking protein that stabilizes centriolar microtubules and inhibits microtubule polymerization and extension from the distal ends of centrioles. Required for centriole elongation and for STIL-mediated centriole amplification. May be involved in the control of centriolar-microtubule growth by acting as a regulator of tubulin release. |
シノニム: | Centromere protein J (CENP-J) (Centrosomal P4.1-associated protein) (LAG-3-associated protein) (LYST-interacting protein 1), CENPJ, CPAP LAP LIP1 |
UniProt Protein Function: | CENPJ: Plays an important role in cell division and centrosome function by participating in centriole duplication. Inhibits microtubule nucleation from the centrosome. Defects in CENPJ are the cause of microcephaly primary type 6 (MCPH6). A disorder defined as a head circumference more than 3 standard deviations below the age- related mean. Brain weight is markedly reduced and the cerebral cortex is disproportionately small. Despite this marked reduction in size, the gyral pattern is relatively well preserved, with no major abnormality in cortical architecture. Primary microcephaly is further defined by the absence of other syndromic features or significant neurological deficits. Defects in CENPJ are the cause of Seckel syndrome type 4 (SCKL4). SCKL4 is a rare autosomal recessive disorder characterized by proportionate dwarfism of prenatal onset associated with low birth weight, growth retardation, severe microcephaly with a bird-headed like appearance, and mental retardation. Belongs to the TCP10 family. |
UniProt Protein Details: | Protein type:Cell cycle regulation; Microtubule-binding; Transcription, coactivator/corepressor Chromosomal Location of Human Ortholog: 13q12.12-q12.13 Cellular Component: centriole; centrosome; cytosol; gamma-tubulin small complex; microtubule; nucleoplasm; plasma membrane Molecular Function:protein binding; protein domain specific binding; protein kinase binding; tubulin binding Biological Process: cell division; centriole replication; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; G2/M transition of mitotic cell cycle; microtubule nucleation; microtubule polymerization; regulation of centriole replication; regulation of G2/M transition of mitotic cell cycle Disease: Microcephaly 6, Primary, Autosomal Recessive; Seckel Syndrome 4 |
NCBI Summary: | This gene encodes a protein that belongs to the centromere protein family. During cell division, this protein plays a structural role in the maintenance of centrosome integrity and normal spindle morphology, and it is involved in microtubule disassembly at the centrosome. This protein can function as a transcriptional coactivator in the Stat5 signaling pathway, and also as a coactivator of NF-kappaB-mediated transcription, likely via its interaction with the coactivator p300/CREB-binding protein. Mutations in this gene are associated with primary autosomal recessive microcephaly, a disorder characterized by severely reduced brain size and cognitive disability. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Apr 2012] |
UniProt Code: | Q9HC77 |
NCBI GenInfo Identifier: | 130980075 |
NCBI Gene ID: | 55835 |
NCBI Accession: | NP_060921.3 |
UniProt Secondary Accession: | Q9HC77,Q2KHM6, Q5JPD5, Q5T6R5, Q96KS5, Q9C067, |
UniProt Related Accession: | Q9HC77 |
Molecular Weight: | 124,244 Da |
NCBI Full Name: | centromere protein J |
NCBI Synonym Full Names: | centromere protein J |
NCBI Official Symbol: | CENPJ |
NCBI Official Synonym Symbols: | LAP; CPAP; LIP1; BM032; MCPH6; SASS4; SCKL4; Sas-4; CENP-J |
NCBI Protein Information: | centromere protein J |
UniProt Protein Name: | Centromere protein J |
UniProt Synonym Protein Names: | Centrosomal P4.1-associated protein; LAG-3-associated protein; LYST-interacting protein 1 |
Protein Family: | Centromere protein |
UniProt Gene Name: | CENPJ |