CDKN2AIP Antibody (PACO14811)
- SKU:
- PACO14811
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | CDKN2AIP Antibody (PACO14811) |
抗体コード: | PACO14811 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, IHC |
推奨される希釈: | ELISA:1:1000-1:5000, IHC:1:50-1:200 |
反応性: | Human |
免疫原: | Fusion protein of human CDKN2AIP |
憲法: | Liquid |
ストレージバッファ: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
精製方法: | Antigen affinity purification |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
![]() | The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO14811(CDKN2AIP Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: x200). |
バックグラウンド: | CDKN2AIP (CDKN2A-interacting protein), also known as CARF, is a 580 amino acid, protein that activates p53 via p14 ARF (alternate reading frame)-dependent and independent pathways. CDKN2AIP-dependent activation of p53, a protein that up-regulates growth arrest and apoptosis-related genes in response to stress signals, leads to an enhancement of p53 function. Expression levels of CDKN2AIP and p53 show an inverse relationship that is caused by a negative-feedback control via a proteasome-mediated degradation pathway. CDKN2AIP is expressed ubiquitously across tissue samples and, along with p14 ARF, is localized to the perinucleolar region within the nucleus. |
シノニム: | CDKN2A interacting protein |
UniProt Protein Function: | CDKN2AIP: co-localizes and interacts with p14ARF in the nucleolus. Co-regulated with ARF and cooperates with it in activating p53. |
UniProt Protein Details: | Protein type:Unknown function Chromosomal Location of Human Ortholog: 4q35.1 Cellular Component: nucleoplasm; granular component; cytoplasm; nucleolus; nucleus Molecular Function:protein binding; RNA binding; p53 binding Biological Process: positive regulation of signal transduction; regulation of protein stability; negative regulation of cell growth; response to DNA damage stimulus; positive regulation of cell growth |
NCBI Summary: | The protein encoded by this gene regulates the DNA damage response through several different signaling pathways. One such pathway is the p53-HDM2-p21(WAF1) pathway, which is critical to the DNA damage response. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015] |
UniProt Code: | Q9NXV6 |
NCBI GenInfo Identifier: | 327478591 |
NCBI Gene ID: | 55602 |
NCBI Accession: | Q9NXV6.3 |
UniProt Related Accession: | Q9NXV6 |
Molecular Weight: | |
NCBI Full Name: | CDKN2A-interacting protein |
NCBI Synonym Full Names: | CDKN2A interacting protein |
NCBI Official Symbol: | CDKN2AIP |
NCBI Official Synonym Symbols: | CARF |
NCBI Protein Information: | CDKN2A-interacting protein |
UniProt Protein Name: | CDKN2A-interacting protein |
UniProt Synonym Protein Names: | Collaborator of ARF |
Protein Family: | Calcium-responsive transcription factor |
UniProt Gene Name: | CDKN2AIP |
UniProt Entry Name: | CARF_HUMAN |