CDK5RAP2 Antibody (PACO52662)
- SKU:
- PACO52662
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
抗体名: | CDK5RAP2 Antibody (PACO52662) |
抗体コード: | PACO52662 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, IHC, IF |
推奨される希釈: | ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:50-1:200 |
反応性: | Human |
免疫原: | Recombinant Human CDK5 regulatory subunit-associated protein 2 protein (996-1111AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
![]() | Immunohistochemistry of paraffin-embedded human kidney tissue using PACO52662 at dilution of 1:100. |
![]() | Immunofluorescent analysis of A549 cells using PACO52662 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
![]() | Immunohistochemistry of paraffin-embedded human brain tissue using PACO52662 at dilution of 1:100. |
バックグラウンド: | Potential regulator of CDK5 activity via its interaction with CDK5R1. Negative regulator of centriole disengagement (licensing) which maintains centriole engagement and cohesion. Involved in regulation of mitotic spindle orientation (By similarity). Plays a role in the spindle checkpoint activation by acting as a transcriptional regulator of both BUBR1 and MAD2 promoter. Together with MAPRE1, it may promote microtubule polymerization, bundle formation, growth and dynamics at the plus ends. Regulates centrosomal maturation by recruitment of a gamma-tubulin ring complex onto centrosomes. |
シノニム: | CDK5 regulatory subunit-associated protein 2 (CDK5 activator-binding protein C48) (Centrosome-associated protein 215), CDK5RAP2, CEP215 KIAA1633 |
UniProt Protein Function: | CDK5RAP2: Potential regulator of CDK5 activity via its interaction with CDK5R1. Negative regulator of centriole disengagement (licensing) which maintains centriole engagement and cohesion. Involved in regulation of mitotic spindle orientation. Plays a role in the spindle checkpoint activation by acting as a transcriptional regulator of both BUBR1 and MAD2 promoter. Together with MAPRE1, it may promote microtubule polymerization, bundle formation, growth and dynamics at the plus ends. Defects in CDK5RAP2 are the cause of microcephaly primary type 3 (MCPH3). A disorder defined as a head circumference more than 3 standard deviations below the age- related mean. Brain weight is markedly reduced and the cerebral cortex is disproportionately small. Despite this marked reduction in size, the gyral pattern is relatively well preserved, with no major abnormality in cortical architecture. Primary microcephaly is further defined by the absence of other syndromic features or significant neurological deficits. 4 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Cytoskeletal Chromosomal Location of Human Ortholog: 9q33.2 Cellular Component: Golgi apparatus; spindle pole; centrosome; microtubule; pericentriolar material; cytoskeleton; perinuclear region of cytoplasm; cytoplasm; cell junction; cytosol Molecular Function:calmodulin binding; tubulin binding; protein binding; microtubule binding; protein kinase binding Biological Process: regulation of neuron differentiation; positive regulation of transcription, DNA-dependent; organelle organization and biogenesis; microtubule cytoskeleton organization and biogenesis; negative regulation of centriole replication; chromosome segregation; negative regulation of neuron differentiation; establishment of mitotic spindle orientation; neurogenesis; centrosome organization and biogenesis; mitotic cell cycle; brain development; G2/M transition of mitotic cell cycle; microtubule bundle formation Disease: Microcephaly 3, Primary, Autosomal Recessive |
NCBI Summary: | This gene encodes a regulator of CDK5 (cyclin-dependent kinase 5) activity. The protein encoded by this gene is localized to the centrosome and Golgi complex, interacts with CDK5R1 and pericentrin (PCNT), plays a role in centriole engagement and microtubule nucleation, and has been linked to primary microcephaly and Alzheimer's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013] |
UniProt Code: | Q96SN8 |
NCBI GenInfo Identifier: | 58535451 |
NCBI Gene ID: | 55755 |
NCBI Accession: | NP_060719.4 |
UniProt Related Accession: | Q96SN8 |
Molecular Weight: | |
NCBI Full Name: | CDK5 regulatory subunit-associated protein 2 isoform a |
NCBI Synonym Full Names: | CDK5 regulatory subunit associated protein 2 |
NCBI Official Symbol: | CDK5RAP2 |
NCBI Official Synonym Symbols: | C48; MCPH3; Cep215 |
NCBI Protein Information: | CDK5 regulatory subunit-associated protein 2 |
UniProt Protein Name: | CDK5 regulatory subunit-associated protein 2 |
UniProt Synonym Protein Names: | CDK5 activator-binding protein C48; Centrosome-associated protein 215 |
Protein Family: | CDK5 regulatory subunit-associated protein |
UniProt Gene Name: | CDK5RAP2 |
UniProt Entry Name: | CK5P2_HUMAN |