CDH3 Antibody, HRP conjugated (PACO32897)
- SKU:
- PACO32897
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- HRP
Description
抗体名: | CDH3 Antibody, HRP conjugated (PACO32897) |
抗体コード: | PACO32897 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Cadherin-3 protein (117-360AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | HRP |
バックグラウンド: | Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. |
シノニム: | Cadherin-3 (Placental cadherin) (P-cadherin), CDH3, CDHP |
UniProt Protein Function: | CDH3: Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Interacts with CDCP1. Expressed in some normal epithelial tissues and in some carcinoma cell lines. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Cell adhesion; Motility/polarity/chemotaxis; Membrane protein, integral Chromosomal Location of Human Ortholog: 16q22.1 Cellular Component: cell-cell adherens junction; cytoplasm; integral to membrane; plasma membrane Molecular Function:calcium ion binding Biological Process: positive regulation of insulin-like growth factor receptor signaling pathway; response to drug; intercellular junction assembly and maintenance; wound healing; positive regulation of melanin biosynthetic process; Wnt receptor signaling pathway through beta-catenin; negative regulation of transforming growth factor-beta2 production; retinal homeostasis; hair cycle process; cell-cell adhesion; positive regulation of monophenol monooxygenase activity; negative regulation of catagen; visual perception; keratinization; cell adhesion; homophilic cell adhesion Disease: Ectodermal Dysplasia, Ectrodactyly, And Macular Dystrophy Syndrome; Hypotrichosis, Congenital, With Juvenile Macular Dystrophy |
NCBI Summary: | This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. This gene is located in a six-cadherin cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. In addition, aberrant expression of this protein is observed in cervical adenocarcinomas. Mutations in this gene have been associated with congential hypotrichosis with juvenile macular dystrophy. [provided by RefSeq, Jul 2008] |
UniProt Code: | P22223 |
NCBI GenInfo Identifier: | 146345382 |
NCBI Gene ID: | 1001 |
NCBI Accession: | P22223.2 |
UniProt Secondary Accession: | P22223,Q05DI6, B2R6F4, |
UniProt Related Accession: | P22223 |
Molecular Weight: | 86,552 Da |
NCBI Full Name: | Cadherin-3 |
NCBI Synonym Full Names: | cadherin 3, type 1, P-cadherin (placental) |
NCBI Official Symbol: | CDH3 |
NCBI Official Synonym Symbols: | CDHP; HJMD; PCAD |
NCBI Protein Information: | cadherin-3; calcium-dependent adhesion protein, placental |
UniProt Protein Name: | Cadherin-3 |
UniProt Synonym Protein Names: | Placental cadherin; P-cadherin |
UniProt Gene Name: | CDH3 |
UniProt Entry Name: | CADH3_HUMAN |