UniProt Protein Function: | CDC5L: is a spliceosome protein that binds DNA and that also regulates transcription. Is a positive regulator of cell cycle G2/M progression. Is an essential component of non-snRNA spliceosomes and is required for the second catalytic step of pre-mRNA splicing. Binds adeno-pre-mRNA in an ATP-stimulated manner. Is part of a spliceosomal 'core' complex that includes CDC5L, SF2, PRLI, SPF27, HSP7C, PRPF19/SNEV, GCN1L. Identified in the spliceosome C complex. Has been associated with aneuploidy in aging cells and in tumorigenesis. The genomic region containing the gene for CDC5L (6p21.1) is frequently amplified in osteosarcomas. |
UniProt Protein Details: | Protein type:DNA-binding; RNA processing; Transcription factor; Spliceosome; Motility/polarity/chemotaxis; RNA splicing Chromosomal Location of Human Ortholog: 6p21 Cellular Component: nucleoplasm; DNA replication factor A complex; membrane; cytoplasm; nucleolus; nuclear speck; nucleus Molecular Function:protein binding; DNA binding; chromatin binding Biological Process: nuclear mRNA splicing, via spliceosome; transcription, DNA-dependent; regulation of transcription, DNA-dependent; RNA splicing; gene expression; DNA repair |
NCBI Summary: | The protein encoded by this gene shares a significant similarity with Schizosaccharomyces pombe cdc5 gene product, which is a cell cycle regulator important for G2/M transition. This protein has been demonstrated to act as a positive regulator of cell cycle G2/M progression. It was also found to be an essential component of a non-snRNA spliceosome, which contains at least five additional protein factors and is required for the second catalytic step of pre-mRNA splicing. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q99459 |
NCBI GenInfo Identifier: | 73619933 |
NCBI Gene ID: | 988 |
NCBI Accession: | Q99459.2 |
UniProt Related Accession: | Q99459 |
Molecular Weight: | 100kDa |
NCBI Full Name: | Cell division cycle 5-like protein |
NCBI Synonym Full Names: | cell division cycle 5 like |
NCBI Official Symbol: | CDC5L |
NCBI Official Synonym Symbols: | CDC5; CEF1; PCDC5RP; CDC5-LIKE; dJ319D22.1 |
NCBI Protein Information: | cell division cycle 5-like protein |
UniProt Protein Name: | Cell division cycle 5-like protein |
UniProt Synonym Protein Names: | Pombe cdc5-related protein |
Protein Family: | CDC50 family protein |
UniProt Gene Name: | CDC5L |
UniProt Entry Name: | CDC5L_HUMAN |