CD33 Antibody (PACO15981)
- SKU:
- PACO15981
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | CD33 Antibody (PACO15981) |
抗体コード: | PACO15981 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC |
推奨される希釈: | ELISA:1:2000-1:5000, WB:1:500-1:2000, IHC:1:25-1:100 |
反応性: | Human |
免疫原: | Fusion protein of human CD33 |
憲法: | Liquid |
ストレージバッファ: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
精製方法: | Antigen affinity purification |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO15981(CD33 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: x200). | |
Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Human testis tissue, Human placenta tissue, Primary antibody: PACO15981(CD33 Antibody) at dilution 1/450, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 30 seconds. | |
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO15981(CD33 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: x200). |
バックグラウンド: | CD33 or Siglec-3 is a transmembrane receptor expressed on cells of myeloid lineage. It is usually considered myeloid-specific, but it can also be found on some lymphoid cells. Putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid, dependent binding to cells. Preferentially binds to alpha-2,6-linked sialic acid, The sialic acid, recognition site may be masked by cis interactions with sialic acid, on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. |
シノニム: | CD33 molecule |
UniProt Protein Function: | CD33: Putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Induces apoptosis in acute myeloid leukemia (in vitro). Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family. |
UniProt Protein Details: | Protein type:Membrane protein, integral; Cell adhesion Chromosomal Location of Human Ortholog: 19q13.3 Cellular Component: integral to plasma membrane; plasma membrane; external side of plasma membrane Molecular Function:protein binding; receptor activity; carbohydrate binding Biological Process: negative regulation of cell proliferation; cell-cell signaling; signal transduction; cell adhesion |
UniProt Code: | P20138 |
NCBI GenInfo Identifier: | 116241290 |
NCBI Gene ID: | 945 |
NCBI Accession: | P20138.2 |
UniProt Secondary Accession: | P20138,Q8TD24, B4E3P8, C9JEN7, F8WAL2, |
UniProt Related Accession: | P20138 |
Molecular Weight: | Calculated MW: 25kDa/33kDa/39kDaObserved MW: 77kDa |
NCBI Full Name: | Myeloid cell surface antigen CD33 |
NCBI Synonym Full Names: | CD33 molecule |
NCBI Official Symbol: | CD33 |
NCBI Official Synonym Symbols: | p67; SIGLEC3; SIGLEC-3 |
NCBI Protein Information: | myeloid cell surface antigen CD33; gp67; CD33 antigen (gp67); sialic acid binding Ig-like lectin 3; sialic acid-binding Ig-like lectin 3 |
UniProt Protein Name: | Myeloid cell surface antigen CD33 |
UniProt Synonym Protein Names: | Sialic acid-binding Ig-like lectin 3; Siglec-3; gp67; CD_antigen: CD33 |
Protein Family: | Myeloid cell surface antigen |
UniProt Gene Name: | CD33 |
UniProt Entry Name: | CD33_HUMAN |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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