CD320 Antibody (PACO45310)
- SKU:
- PACO45310
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | CD320 Antibody (PACO45310) |
抗体コード: | PACO45310 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, IHC |
推奨される希釈: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
反応性: | Human |
免疫原: | Recombinant Human CD320 antigen protein (36-229AA) |
憲法: | Liquid |
ストレージバッファ: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
精製方法: | Antigen Affinity Purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
![]() | Immunohistochemistry of paraffin-embedded human tonsil tissue using PACO45310 at dilution of 1:100. |
![]() | Immunohistochemistry of paraffin-embedded human spleen tissue using PACO45310 at dilution of 1:100. |
バックグラウンド: | Germinal center-B (GC-B) cells differentiate into memory B-cells and plasma cells (PC) through interaction with T-cells and follicular dendritic cells (FDC). CD320 augments the proliferation of PC precursors generated by IL-10. Receptor for the cellular uptake of transcobalamin bound cobalamin. |
シノニム: | CD320 antigen (8D6 antigen) (FDC-signaling molecule 8D6) (FDC-SM-8D6) (Transcobalamin receptor) (TCblR) (CD antigen CD320), CD320, 8D6A |
UniProt Protein Function: | Receptor for transcobalamin saturated with cobalamin (TCbl) (PubMed:18779389). Plays an important role in cobalamin uptake (PubMed:18779389, PubMed:20524213). Plasma membrane protein that is expressed on follicular dendritic cells (FDC) and mediates interaction with germinal center B cells (PubMed:10727470). Functions as costimulator to promote B cell responses to antigenic stimuli; promotes B cell differentiation and proliferation (PubMed:10727470, PubMed:11418631). Germinal center-B (GC-B) cells differentiate into memory B-cells and plasma cells (PC) through interaction with T-cells and follicular dendritic cells (FDC) (PubMed:11418631). CD320 augments the proliferation of PC precursors generated by IL-10 (PubMed:11418631). |
NCBI Summary: | This gene encodes the transcobalamin receptor that is expressed at the cell surface. It mediates the cellular uptake of transcobalamin bound cobalamin (vitamin B12), and is involved in B-cell proliferation and immunoglobulin secretion. Mutations in this gene are associated with methylmalonic aciduria. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2011] |
UniProt Code: | Q9NPF0 |
NCBI GenInfo Identifier: | 74734303 |
NCBI Gene ID: | 51293 |
NCBI Accession: | Q9NPF0.1 |
UniProt Secondary Accession: | Q9NPF0,Q53HF7, B2RDS5, D6W668, F5H6D3, |
UniProt Related Accession: | Q9NPF0 |
Molecular Weight: | 24,371 Da |
NCBI Full Name: | CD320 antigen |
NCBI Synonym Full Names: | CD320 molecule |
NCBI Official Symbol: | CD320 |
NCBI Official Synonym Symbols: | 8D6; 8D6A; TCBLR |
NCBI Protein Information: | CD320 antigen |
UniProt Protein Name: | CD320 antigen |
UniProt Synonym Protein Names: | 8D6 antigen |
Protein Family: | CD320 antigen |
UniProt Gene Name: | CD320 |
Antibodies | ELISA Kits |
Anti-CD320 antigen Antibody (CAB8627) | Human CD320 ELISA Kit (HUFI03455) |
CD320 Antibody (PACO08283) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |