CCR4 Antibody (PACO03422)
- SKU:
- PACO03422
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | CCR4 Antibody |
抗体コード: | PACO03422 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, IF |
推奨される希釈: | IF:1:200-1:1000 |
反応性: | Human, Mouse, Rat |
免疫原: | synthesized peptide derived from the Internal region of human CKR-4. |
憲法: | Liquid |
ストレージバッファ: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
精製方法: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
シノニム: | CCR4; CMKBR4; C-C chemokine receptor type 4; C-C CKR-4; CC-CKR-4; CCR-4; CCR4; K5-5; CD antigen CD194 |
UniProt Protein Function: | CCR4: High affinity receptor for the C-C type chemokines CCL17/TARC and CCL22/MDC. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol- calcium second messenger system. Can function as a chemoattractant homing receptor on circulating memory lymphocytes and as a coreceptor for some primary HIV-2 isolates. In the CNS, could mediate hippocampal-neuron survival. Belongs to the G-protein coupled receptor 1 family. |
UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Receptor, GPCR; Membrane protein, multi-pass; Membrane protein, integral; GPCR, family 1 Chromosomal Location of Human Ortholog: 3p24 Cellular Component: cell soma; integral to plasma membrane; plasma membrane; external side of plasma membrane Molecular Function:C-C chemokine receptor activity; chemokine receptor activity Biological Process: response to antibiotic; G-protein coupled receptor protein signaling pathway; elevation of cytosolic calcium ion concentration; response to radiation; positive regulation of positive chemotaxis; response to bacterium; neuron migration; immune response; inflammatory response; chemotaxis; tolerance induction |
NCBI Summary: | The protein encoded by this gene belongs to the G-protein-coupled receptor family . It is a receptor for the CC chemokine - MIP-1, RANTES, TARC and MCP-1. Chemokines are a group of small polypeptide, structurally related molecules that regulate cell trafficking of various types of leukocytes. The chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. [provided by RefSeq, Jul 2008] |
UniProt Code: | P51679 |
NCBI GenInfo Identifier: | 1705894 |
NCBI Gene ID: | 1233 |
NCBI Accession: | P51679.1 |
UniProt Secondary Accession: | P51679,Q9ULY6, Q9ULY7, |
UniProt Related Accession: | P51679 |
Molecular Weight: | 41,403 Da |
NCBI Full Name: | C-C chemokine receptor type 4 |
NCBI Synonym Full Names: | chemokine (C-C motif) receptor 4 |
NCBI Official Symbol: | CCR4 |
NCBI Official Synonym Symbols: | CKR4; K5-5; CD194; CMKBR4; ChemR13; CC-CKR-4; HGCN:14099 |
NCBI Protein Information: | C-C chemokine receptor type 4; C-C CKR-4; CCR-4; chemokine (C-C) receptor 4 |
UniProt Protein Name: | C-C chemokine receptor type 4 |
UniProt Synonym Protein Names: | K5-5; CD_antigen: CD194 |
Protein Family: | C-C chemokine receptor |
UniProt Gene Name: | CCR4 |
UniProt Entry Name: | CCR4_HUMAN |