CCL11 Antibody (PACO02120)
- SKU:
- PACO02120
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
抗体名: | CCL11 Antibody |
抗体コード: | PACO02120 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, WB |
推奨される希釈: | WB:1:500-1:2000 |
反応性: | Human, Mouse, Rat |
免疫原: | synthesized peptide derived from the Internal region of human Eotaxin. |
憲法: | Liquid |
ストレージバッファ: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
精製方法: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
シノニム: | CCL11; SCYA11; Eotaxin; C-C motif chemokine 11; Eosinophil chemotactic protein; Small-inducible cytokine A11 |
UniProt Protein Function: | CCL11: In response to the presence of allergens, this protein directly promotes the accumulation of eosinophils, a prominent feature of allergic inflammatory reactions. Binds to CCR3. Belongs to the intercrine beta (chemokine CC) family. |
UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: 17q12 Cellular Component: extracellular region; extracellular space; intracellular Molecular Function:CCR chemokine receptor binding; chemokine activity; protein binding Biological Process: actin filament organization; cell adhesion; cellular calcium ion homeostasis; chemotaxis; chronic inflammatory response; cytoskeleton organization and biogenesis; eosinophil chemotaxis; G-protein coupled receptor protein signaling pathway; inflammatory response; lymphocyte chemotaxis; mast cell chemotaxis; monocyte chemotaxis; neutrophil chemotaxis; positive regulation of actin filament polymerization; positive regulation of angiogenesis; positive regulation of cell migration; positive regulation of endothelial cell proliferation; positive regulation of GTPase activity; positive regulation of inflammatory response; protein amino acid phosphorylation; regulation of cell shape; response to radiation; response to virus; signal transduction Disease: Asthma, Susceptibility To; Human Immunodeficiency Virus Type 1, Susceptibility To |
NCBI Summary: | This antimicrobial gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, displays chemotactic activity for eosinophils, but not mononuclear cells or neutrophils. This eosinophil-specific chemokine is thought to be involved in eosinophilic inflammatory diseases such as atopic dermatitis, allergic rhinitis, asthma and parasitic infections. [provided by RefSeq, Sep 2014] |
UniProt Code: | P51671 |
NCBI GenInfo Identifier: | 1706661 |
NCBI Gene ID: | 6356 |
NCBI Accession: | P51671.1 |
UniProt Secondary Accession: | P51671,P50877, Q92490, Q92491, |
UniProt Related Accession: | P51671 |
Molecular Weight: | 10,732 Da |
NCBI Full Name: | Eotaxin |
NCBI Synonym Full Names: | C-C motif chemokine ligand 11 |
NCBI Official Symbol: | CCL11 |
NCBI Official Synonym Symbols: | SCYA11 |
NCBI Protein Information: | eotaxin |
UniProt Protein Name: | Eotaxin |
UniProt Synonym Protein Names: | C-C motif chemokine 11; Eosinophil chemotactic protein; Small-inducible cytokine A11 |
Protein Family: | Eotaxin |
UniProt Gene Name: | CCL11 |
UniProt Entry Name: | CCL11_HUMAN |