CBR1 Antibody (PACO15760)
- SKU:
- PACO15760
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | CBR1 Antibody (PACO15760) |
抗体コード: | PACO15760 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC |
推奨される希釈: | ELISA:1:2000-1:10000, WB:1:1000-1:5000, IHC:1:50-1:200 |
反応性: | Human, Mouse, Rat |
免疫原: | Fusion protein of human CBR1 |
憲法: | Liquid |
ストレージバッファ: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
精製方法: | Antigen affinity purification |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
![]() | The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using PACO15760(CBR1 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: x200). |
![]() | Gel: 15%SDS-PAGE, Lysate: 40 μg, Lane 1-5: Mouse liver tissue, human fetal lung tissue, hela cells, mouse kidney tissue, human brain malignant glioma tissue, Primary antibody: PACO15760(CBR1 Antibody) at dilution 1/900, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds. |
![]() | The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using PACO15760(CBR1 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: x200). |
バックグラウンド: | Carbonyl reductase is one of several monomeric, NADPH-dependent oxidoreductases having wide specificity for carbonyl compounds. This enzyme is widely distributed in human tissues. Another carbonyl reductase gene, CRB3, lies close to this gene on chromosome 21q. NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol. |
シノニム: | carbonyl reductase 1 |
UniProt Protein Function: | CBR1: NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol. Can convert prostaglandin E2 to prostaglandin F2-alpha. Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S-nitrosoglutathione. Belongs to the short-chain dehydrogenases/reductases (SDR) family. |
UniProt Protein Details: | Protein type:EC 1.1.1.189; Lipid Metabolism - arachidonic acid; EC 1.1.1.197; Oxidoreductase; EC 1.1.1.184 Chromosomal Location of Human Ortholog: 21q22.13 Cellular Component: cytosol; vesicle Molecular Function:oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor; prostaglandin-E2 9-reductase activity; 15-hydroxyprostaglandin dehydrogenase (NADP+) activity; carbonyl reductase (NADPH) activity Biological Process: epithelial cell differentiation; vitamin K metabolic process; cyclooxygenase pathway; arachidonic acid metabolic process; drug metabolic process |
NCBI Summary: | The protein encoded by this gene belongs to the short-chain dehydrogenases/reductases (SDR) family, which function as NADPH-dependent oxidoreductases having wide specificity for carbonyl compounds, such as quinones, prostaglandins, and various xenobiotics. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2013] |
UniProt Code: | P16152 |
NCBI GenInfo Identifier: | 118519 |
NCBI Gene ID: | 873 |
NCBI Accession: | P16152.3 |
UniProt Secondary Accession: | P16152,Q3LHW8, B2RBZ7, B4DFK7, |
UniProt Related Accession: | P16152 |
Molecular Weight: | 277 |
NCBI Full Name: | Carbonyl reductase |
NCBI Synonym Full Names: | carbonyl reductase 1 |
NCBI Official Symbol: | CBR1 |
NCBI Official Synonym Symbols: | CBR; hCBR1; SDR21C1 |
NCBI Protein Information: | carbonyl reductase [NADPH] 1; carbonyl reductase [NADPH] 1; carbonyl reductase (NADPH) 1; prostaglandin 9-ketoreductase; prostaglandin-E(2) 9-reductase; NADPH-dependent carbonyl reductase 1; 15-hydroxyprostaglandin dehydrogenase; short chain dehydrogenase/reductase family 21C, member 1 |
UniProt Protein Name: | Carbonyl reductase [NADPH] 1 |
UniProt Synonym Protein Names: | 15-hydroxyprostaglandin dehydrogenase [NADP(+)] (EC:1.1.1.197); NADPH-dependent carbonyl reductase 1; Prostaglandin 9-ketoreductase; Prostaglandin-E(2) 9-reductase (EC:1.1.1.189) |
Protein Family: | Carbonyl reductase |
UniProt Gene Name: | CBR1 |
UniProt Entry Name: | CBR1_HUMAN |
Antibodies | ELISA Kits |
Anti-CBR1 Antibody (CAB5446) | Human CBR1 (Carbonyl reductase [NADPH] 1) ELISA KIT (HUFI05390) |
Anti-CBR1 Antibody (CAB18074)[KO Validated] | |
CBR1 Antibody (PACO03161) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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