CASQ2 Antibody (PACO54674)
- SKU:
- PACO54674
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
抗体名: | CASQ2 Antibody (PACO54674) |
抗体コード: | PACO54674 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC |
推奨される希釈: | ELISA:1:2000-1:10000, WB:1:500-1:5000, IHC:1:20-1:200 |
反応性: | Human |
免疫原: | Recombinant Human Calsequestrin-2 protein (219-300AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
![]() | Western Blot. Positive WB detected in: MCF-7 whole cell lysate. All lanes: CASQ2 antibody at 3µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 47, 39 kDa. Observed band size: 47 kDa. |
![]() | Immunohistochemistry of paraffin-embedded human skeletal muscle tissue using PACO54674 at dilution of 1:100. |
バックグラウンド: | Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle. Calcium ions are bound by clusters of acid, c residues at the protein surface, especially at the interface between subunits. Can bind around 60 Ca(2+) ions. Regulates the release of lumenal Ca(2+) via the calcium release channel RYR2; this plays an important role in triggering muscle contraction. Plays a role in excitation-contraction coupling in the heart and in regulating the rate of heart beats. |
シノニム: | Calsequestrin-2 (Calsequestrin, cardiac muscle isoform), CASQ2 |
UniProt Protein Function: | calsequestrin 2: Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle. The release of calcium bound to calsequestrin through a calcium release channel triggers muscle contraction. The skeletal muscle isoform (CASQ1) binds around 80 Ca(2+) ions, while the cardiac isoform (CASQ2) binds approximately 60 Ca(2+) ions. Defects in CASQ2 are the cause of catecholaminergic polymorphic ventricular tachycardia type 2 (CPVT2); also known as stress-induced polymorphic ventricular tachycardia (VTSIP). CPVT2 is an autosomal recessive form of arrhythmogenic disorder characterized by stress-induced, bidirectional ventricular tachycardia that may degenerate into cardiac arrest and cause sudden death. Belongs to the calsequestrin family. |
UniProt Protein Details: | Protein type:Calcium-binding Chromosomal Location of Human Ortholog: 1p13.1 Cellular Component: sarcoplasmic reticulum membrane; sarcoplasmic reticulum lumen; sarcoplasmic reticulum; junctional membrane complex; cytoplasm; voltage-gated calcium channel complex; intracellular; Z disc Molecular Function:protein binding; protein homodimerization activity; calcium ion binding; calcium-dependent protein binding Biological Process: protein polymerization; striated muscle contraction; regulation of heart rate; negative regulation of potassium ion transport; sequestering of calcium ion; detection of calcium ion; sarcomere organization; transmembrane transport; cardiac muscle contraction Disease: Ventricular Tachycardia, Catecholaminergic Polymorphic, 1, With Or Without Atrial Dysfunction And/or Dilated Cardiomyopathy; Ventricular Tachycardia, Catecholaminergic Polymorphic, 2 |
NCBI Summary: | The protein encoded by this gene specifies the cardiac muscle family member of the calsequestrin family. Calsequestrin is localized to the sarcoplasmic reticulum in cardiac and slow skeletal muscle cells. The protein is a calcium binding protein that stores calcium for muscle function. Mutations in this gene cause stress-induced polymorphic ventricular tachycardia, also referred to as catecholaminergic polymorphic ventricular tachycardia 2 (CPVT2), a disease characterized by bidirectional ventricular tachycardia that may lead to cardiac arrest. [provided by RefSeq, Jul 2008] |
UniProt Code: | O14958 |
NCBI GenInfo Identifier: | 119395727 |
NCBI Gene ID: | 845 |
NCBI Accession: | NP_001223.2 |
UniProt Secondary Accession: | O14958,Q5T1D2, Q8TBW8, B2R7M6, |
UniProt Related Accession: | O14958 |
Molecular Weight: | 46,436 Da |
NCBI Full Name: | calsequestrin-2 |
NCBI Synonym Full Names: | calsequestrin 2 (cardiac muscle) |
NCBI Official Symbol: | CASQ2 |
NCBI Official Synonym Symbols: | PDIB2 |
NCBI Protein Information: | calsequestrin-2; calsequestrin, cardiac muscle isoform; calsequestrin 2, fast-twitch, cardiac muscle |
UniProt Protein Name: | Calsequestrin-2 |
UniProt Synonym Protein Names: | Calsequestrin, cardiac muscle isoform |
Protein Family: | Calsequestrin |
UniProt Gene Name: | CASQ2 |
UniProt Entry Name: | CASQ2_HUMAN |