CARD16 Antibody (PACO63799)
- SKU:
- PACO63799
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | CARD16 Antibody (PACO63799) |
抗体コード: | PACO63799 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, IF |
推奨される希釈: | ELISA:1:2000-1:10000, IF:1:50-1:200 |
反応性: | Human |
免疫原: | Recombinant Human Caspase recruitment domain-containing protein 16 protein (1-197AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | Antigen Affinity Purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
![]() | Immunofluorescence staining of Hela cells with PACO63799 at 1:50, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
バックグラウンド: | Caspase inhibitor. Acts as a regulator of procaspase-1/CASP1 activation implicated in the regulation of the proteolytic maturation of pro-interleukin-1 β (IL1B) and its release during inflammation. Inhibits the release of IL1B in response to LPS in monocytes. Also induces NF-kappa-B activation during the pro-inflammatory cytokine response. Also able to inhibit CASP1-mediated neuronal cell death, TNF-alpha, hypoxia-, UV-, and staurosporine-mediated cell death but not ER stress-mediated cell death. Acts by preventing activation of caspases CASP1 and CASP4, possibly by preventing the interaction between CASP1 and RIPK2. |
シノニム: | Caspase recruitment domain-containing protein 16 (Caspase recruitment domain-only protein 1) (CARD-only protein 1) (Caspase-1 inhibitor COP) (Pseudo interleukin-1 β converting enzyme) (Pseudo-ICE) (Pseudo-IL1B-converting enzyme), CARD16, COP COP1 |
UniProt Protein Function: | CARD16: Caspase inhibitor. Acts as a regulator of procaspase- 1/CASP1 activation implicated in the regulation of the proteolytic maturation of pro-interleukin-1 beta (IL1B) and its release during inflammation. Inhibits the release of IL1B in response to LPS in monocytes. Also induces NF-kappa-B activation during the pro- inflammatory cytokine response. Also able to inhibit CASP1- mediated neuronal cell death, TNF-alpha, hypoxia-, UV-, and staurosporine-mediated cell death but not ER stress-mediated cell death. Acts by preventing activation of caspases CASP1 and CASP4, possibly by preventing the interaction between CASP1 and RIPK2. Down-regulated in patients suffering of Huntington disease. Homooligomer. Interacts with CASP1, CASP4, CARD8 and RIPK2. 2 isoforms of the human protein are produced by alternative splicing |
UniProt Protein Details: | Chromosomal Location of Human Ortholog: 11q22 |
UniProt Code: | Q5EG05 |
NCBI GenInfo Identifier: | 74722547 |
NCBI Gene ID: | 114769 |
NCBI Accession: | Q5EG05.1 |
UniProt Secondary Accession: | Q5EG05,Q96RJ9, |
UniProt Related Accession: | Q5EG05 |
Molecular Weight: | 10,737 Da |
NCBI Full Name: | Caspase recruitment domain-containing protein 16 |
NCBI Synonym Full Names: | caspase recruitment domain family member 16 |
NCBI Official Symbol: | CARD16 |
NCBI Official Synonym Symbols: | COP; COP1; PSEUDO-ICE |
NCBI Protein Information: | caspase recruitment domain-containing protein 16 |
UniProt Protein Name: | Caspase recruitment domain-containing protein 16 |
UniProt Synonym Protein Names: | Caspase recruitment domain-only protein 1; CARD-only protein 1; Caspase-1 inhibitor COP; Pseudo interleukin-1 beta converting enzyme; Pseudo-ICE; Pseudo-IL1B-converting enzyme |
Protein Family: | Caspase recruitment domain-containing protein |
UniProt Gene Name: | CARD16 |
UniProt Entry Name: | CAR16_HUMAN |
Antibodies |
Anti-CARD16 Antibody (CAB16624) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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