CARD10 Antibody (PACO00509)
- SKU:
- PACO00509
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | CARD10 Antibody |
抗体コード: | PACO00509 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC, IF |
推奨される希釈: | WB:1:500-1:2000, IHC:1:100-1:300, IF:1:200-1:1000 |
反応性: | Human, Mouse |
免疫原: | synthesized peptide derived from the Internal region of human CARD 10. |
憲法: | Liquid |
ストレージバッファ: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
精製方法: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
シノニム: | CARD10; CARMA3; Caspase recruitment domain-containing protein 10; CARD-containing MAGUK protein 3; Carma 3 |
UniProt Protein Function: | CARD10: a protein containing a caspase recruitment domain (CARD) that functions as an activator of BCL10 and NF-kappaB signaling. CARD is a protein module that consists of 6 or 7 antiparallel alpha helices. It participates in apoptosis signaling through highly specific protein-protein homophilic interactions. CARD proteins function as scaffolds for the assembly of multiprotein complexes at specialized regions of the plasma membrane. The CARD domain of CARD14 associates specifically with the CARD domains of CARD10 and BCL10, a signaling protein that activates NF-kB through the IkappaB kinase complex in response to upstream stimuli. When expressed in cells, CARD14 activates NF-kappaB and induces the phosphorylation of BCL10. A subgroup of primary lymphomas of the central nervous system have higher levels of CARD14 expression. |
UniProt Protein Details: | Protein type:Adaptor/scaffold Chromosomal Location of Human Ortholog: 22q13.1 Molecular Function:protein binding Biological Process: activation of NF-kappaB-inducing kinase |
NCBI Summary: | The caspase recruitment domain (CARD) is a protein module that consists of 6 or 7 antiparallel alpha helices. It participates in apoptosis signaling through highly specific protein-protein homophilic interactions. Like several other CARD proteins, CARD10 belongs to the membrane-associated guanylate kinase (MAGUK) family and activates NF-kappa-B (NFKB; see MIM 164011) through BCL10 (MIM 603517) (Wang et al., 2001 [PubMed 11259443]).[supplied by OMIM, Mar 2008] |
UniProt Code: | Q9BWT7 |
NCBI GenInfo Identifier: | 116241281 |
NCBI Gene ID: | 29775 |
NCBI Accession: | Q9BWT7.2 |
UniProt Secondary Accession: | Q9BWT7,Q14CQ8, Q5TFG6, Q8NC81, Q9UGR5, Q9UGR6, Q9Y3H0 |
UniProt Related Accession: | Q9BWT7 |
Molecular Weight: | 82,541 Da |
NCBI Full Name: | Caspase recruitment domain-containing protein 10 |
NCBI Synonym Full Names: | caspase recruitment domain family member 10 |
NCBI Official Symbol: | CARD10 |
NCBI Official Synonym Symbols: | BIMP1; CARMA3 |
NCBI Protein Information: | caspase recruitment domain-containing protein 10 |
UniProt Protein Name: | Caspase recruitment domain-containing protein 10 |
UniProt Synonym Protein Names: | CARD-containing MAGUK protein 3; Carma 3 |
Protein Family: | Caspase recruitment domain-containing protein |
UniProt Gene Name: | CARD10 |
UniProt Entry Name: | CAR10_HUMAN |