Capsid protein VP1 Antibody (PACO34862)

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SKU:
PACO34862
Product type:
Antibody
Reactivity:
Human parvovirus B19
Host Species:
Rabbit
Isotype:
IgG
Application:
ELISA
Antibody type:
Polyclonal
Conjugation:
Unconjugated
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Description

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抗体名:Capsid protein VP1 Antibody (PACO34862)
抗体コード:PACO34862
サイズ:50ug
宿主種:Rabbit
申し込み:ELISA
推奨される希釈:
反応性:Human parvovirus B19
免疫原:Recombinant Human parvovirus B19 Capsid protein VP2 protein (228-781AA)
憲法:Liquid
ストレージバッファ:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
精製方法:>95%, Protein G purified
抗体のクローン性:Polyclonal
アイソタイプ:IgG
Conjugate:Non-conjugated
バックグラウンド:Capsid protein self-assembles to form an icosahedral capsid with a T=1 symmetry, about 22 nm in diameter, and consisting of 60 copies of two size variants of the capsid proteins, VP1 and VP2, which differ by the presence of an N-terminal extension in the minor protein VP1. The capsid encapsulates the genomic ssDNA. Capsid proteins are responsible for the attachment to host cell receptors, such as the glycosphingolipid globoside or the integrin heterodimer ITGAV/ITGB1. This attachment induces virion internalization predominantly through clathrin-dependent endocytosis. Binding to the host receptors also induces capsid rearrangements leading to surface exposure of VP1 N-terminus, specifically its phospholipase A2-like region and nuclear localization signal(s). VP1 N-terminus might serve as a lipolytic enzyme to breach the endosomal membrane during entry into host cell. Intracytoplasmic transport involves microtubules and interaction between capsid proteins and host dynein. Exposure of nuclear localization signal probably allows nuclear import of capsids (By similarity).
シノニム:Capsid protein VP1 (Coat protein VP1) [Cleaved into: Capsid protein VP2 (Coat protein VP2)]
UniProt Protein Function:Capsid protein self-assembles to form an icosahedral capsid with a T=1 symmetry, about 22 nm in diameter, and consisting of 60 copies of two size variants of the capsid proteins, VP1 and VP2, which differ by the presence of an N-terminal extension in the minor protein VP1. The capsid encapsulates the genomic ssDNA. Capsid proteins are responsible for the attachment to host cell receptors, such as the glycosphingolipid globoside or the integrin heterodimer ITGAV/ITGB1. This attachment induces virion internalization predominantly through clathrin-dependent endocytosis. Binding to the host receptors also induces capsid rearrangements leading to surface exposure of VP1 N-terminus, specifically its phospholipase A2-like region and nuclear localization signal(s). VP1 N-terminus might serve as a lipolytic enzyme to breach the endosomal membrane during entry into host cell. Intracytoplasmic transport involves microtubules and interaction between capsid proteins and host dynein. Exposure of nuclear localization signal probably allows nuclear import of capsids ().
UniProt Protein Details:
NCBI Summary:
UniProt Code:P07299
NCBI GenInfo Identifier:116774
NCBI Gene ID:
NCBI Accession:P07299.1
UniProt Secondary Accession:P07299
UniProt Related Accession:P07299
Molecular Weight:
NCBI Full Name:Capsid protein VP1
NCBI Synonym Full Names:
NCBI Official Symbol:
NCBI Official Synonym Symbols:
NCBI Protein Information:
UniProt Protein Name:Capsid protein VP1
UniProt Synonym Protein Names:Coat protein VP1
Protein Family:Capsid protein
UniProt Gene Name:
UniProt Entry Name:CAPSD_PAVHU
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