CAPN1 Antibody (PACO51382)
- SKU:
- PACO51382
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | CAPN1 Antibody (PACO51382) |
抗体コード: | PACO51382 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC |
推奨される希釈: | ELISA:1:2000-1:10000, WB:1:500-1:5000, IHC:1:20-1:200 |
反応性: | Human |
免疫原: | Recombinant Human Calpain-1 catalytic subunit protein (1-714AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
Western Blot. Positive WB detected in: A549 whole cell lysat, K562 whole cell lysate. All lanes: CAPN1 antibody at 2.7µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 82 kDa. Observed band size: 82 kDa.. | |
Immunohistochemistry of paraffin-embedded human lung cancer using PACO51382 at dilution of 1:100. |
バックグラウンド: | Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. |
シノニム: | Calpain-1 catalytic subunit (EC 3.4.22.52) (Calcium-activated neutral proteinase 1) (CANP 1) (Calpain mu-type) (Calpain-1 large subunit) (Cell proliferation-inducing gene 30 protein) (Micromolar-calpain) (muCANP), CAPN1, CANPL1 |
UniProt Protein Function: | CAPN1: Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Forms a heterodimer with a small (regulatory) subunit (CAPNS1). Ubiquitous. Activated by micromolar concentrations of calcium and inhibited by calpastatin. Belongs to the peptidase C2 family. |
UniProt Protein Details: | Protein type:EC 3.4.22.52; Protease; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 11q13 Cellular Component: focal adhesion; membrane; cytoplasm; plasma membrane; cytosol Molecular Function:protein binding; calcium-dependent cysteine-type endopeptidase activity; calcium ion binding Biological Process: extracellular matrix disassembly; extracellular matrix organization and biogenesis; receptor catabolic process; positive regulation of cell proliferation; proteolysis |
NCBI Summary: | The calpains, calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous enzymes consist of heterodimers with distinct large, catalytic subunits associated with a common small, regulatory subunit. This gene encodes the large subunit of the ubiquitous enzyme, calpain 1. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Nov 2010] |
UniProt Code: | P07384 |
NCBI GenInfo Identifier: | 115574 |
NCBI Gene ID: | 823 |
NCBI Accession: | P07384.1 |
UniProt Secondary Accession: | P07384,Q2TTR0, Q6DHV4, |
UniProt Related Accession: | P07384 |
Molecular Weight: | |
NCBI Full Name: | Calpain-1 catalytic subunit |
NCBI Synonym Full Names: | calpain 1, (mu/I) large subunit |
NCBI Official Symbol: | CAPN1 |
NCBI Official Synonym Symbols: | CANP; muCL; CANP1; CANPL1; muCANP |
NCBI Protein Information: | calpain-1 catalytic subunit; CANP 1; calpain mu-type; micromolar-calpain; calpain-1 large subunit; calpain, large polypeptide L1; calcium-activated neutral proteinase 1; cell proliferation-inducing protein 30; cell proliferation-inducing gene 30 protein |
UniProt Protein Name: | Calpain-1 catalytic subunit |
UniProt Synonym Protein Names: | Calcium-activated neutral proteinase 1; CANP 1; Calpain mu-type; Calpain-1 large subunit; Cell proliferation-inducing gene 30 protein; Micromolar-calpain; muCANP |
Protein Family: | Calpain |
UniProt Gene Name: | CAPN1 |
UniProt Entry Name: | CAN1_HUMAN |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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