CAMLG Antibody, HRP conjugated (PACO53231)
- SKU:
- PACO53231
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- HRP
Frequently bought together:
Description
抗体名: | CAMLG Antibody, HRP conjugated (PACO53231) |
抗体コード: | PACO53231 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Calcium signal-modulating cyclophilin ligand protein (1-189AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | HRP |
バックグラウンド: | Likely involved in the mobilization of calcium as a result of the TCR/CD3 complex interaction. Binds to cyclophilin B. |
シノニム: | Calcium signal-modulating cyclophilin ligand (CAML), CAMLG, CAML |
UniProt Protein Function: | CAMLG: Likely involved in the mobilization of calcium as a result of the TCR/CD3 complex interaction. Binds to cyclophilin B. |
UniProt Protein Details: | Protein type:Membrane protein, integral; Membrane protein, multi-pass; Endoplasmic reticulum Chromosomal Location of Human Ortholog: 5q23 Cellular Component: membrane; endoplasmic reticulum; integral to membrane Molecular Function:protein binding; cell adhesion molecule binding Biological Process: receptor recycling; epidermal growth factor receptor signaling pathway; viral reproduction; defense response; signal transduction |
NCBI Summary: | The immunosuppressant drug cyclosporin A blocks a calcium-dependent signal from the T-cell receptor (TCR) that normally leads to T-cell activation. When bound to cyclophilin B, cyclosporin A binds and inactivates the key signaling intermediate calcineurin. The protein encoded by this gene functions similarly to cyclosporin A, binding to cyclophilin B and acting downstream of the TCR and upstream of calcineurin by causing an influx of calcium. This integral membrane protein appears to be a new participant in the calcium signal transduction pathway, implicating cyclophilin B in calcium signaling, even in the absence of cyclosporin. [provided by RefSeq, Jul 2008] |
UniProt Code: | P49069 |
NCBI GenInfo Identifier: | 4502559 |
NCBI Gene ID: | 819 |
NCBI Accession: | NP_001736.1 |
UniProt Secondary Accession: | P49069,P49070, |
UniProt Related Accession: | P49069 |
Molecular Weight: | 32,953 Da |
NCBI Full Name: | calcium signal-modulating cyclophilin ligand |
NCBI Synonym Full Names: | calcium modulating ligand |
NCBI Official Symbol: | CAMLG |
NCBI Official Synonym Symbols: | CAML |
NCBI Protein Information: | calcium signal-modulating cyclophilin ligand; calcium-modulating cyclophilin ligand; calcium-signal modulating cyclophilin ligand; cyclophilin B-binding protein |
UniProt Protein Name: | Calcium signal-modulating cyclophilin ligand |
UniProt Gene Name: | CAMLG |
UniProt Entry Name: | CAMLG_HUMAN |