CALCA Antibody, Biotin conjugated (PACO33183)
- SKU:
- PACO33183
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- Biotin
Frequently bought together:
Description
抗体名: | CALCA Antibody, Biotin conjugated (PACO33183) |
抗体コード: | PACO33183 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Calcitonin gene-related peptide 1 protein (83-118AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Biotin |
バックグラウンド: | CGRP induces vasodilation. It dilates a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role. It also elevates platelet cAMP. |
シノニム: | Calcitonin gene-related peptide 1 (Alpha-type CGRP) (Calcitonin gene-related peptide I) (CGRP-I), CALCA, CALC1 |
UniProt Protein Function: | CALCA iso3: Calcitonin causes a rapid but short-lived drop in the level of calcium and phosphate in blood by promoting the incorporation of those ions in the bones. Belongs to the calcitonin family. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: 11p15.2 Cellular Component: extracellular region; extracellular space Molecular Function:calcitonin receptor binding; identical protein binding; protein binding Biological Process: activation of protein kinase activity; cellular protein metabolic process; elevation of cytosolic calcium ion concentration; elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); embryo implantation; monocyte chemotaxis; negative regulation of bone resorption; negative regulation of transcription, DNA-dependent; positive regulation of adenylate cyclase activity |
NCBI Summary: | This gene encodes the peptide hormones calcitonin, calcitonin gene-related peptide and katacalcin by tissue-specific alternative RNA splicing of the gene transcripts and cleavage of inactive precursor proteins. Calcitonin is involved in calcium regulation and acts to regulate phosphorus metabolism. Calcitonin gene-related peptide functions as a vasodilator and as an antimicrobial peptide while katacalcin is a calcium-lowering peptide. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2014] |
UniProt Code: | P06881 |
NCBI GenInfo Identifier: | 76880478 |
NCBI Gene ID: | 796 |
NCBI Accession: | NP_001029125.1 |
UniProt Secondary Accession: | P06881,Q93048, Q9UCP0, |
UniProt Related Accession: | P01258,P06881 |
Molecular Weight: | 15,466 Da |
NCBI Full Name: | calcitonin gene-related peptide 1 isoform alpha-CGRP preproprotein |
NCBI Synonym Full Names: | calcitonin related polypeptide alpha |
NCBI Official Symbol: | CALCA |
NCBI Official Synonym Symbols: | CT; KC; PCT; CGRP; CALC1; CGRP1; CGRP-I |
NCBI Protein Information: | calcitonin; calcitonin gene-related peptide 1 |
UniProt Protein Name: | Calcitonin gene-related peptide 1 |
UniProt Synonym Protein Names: | Alpha-type CGRP; Calcitonin gene-related peptide I; CGRP-I |
Protein Family: | Calcitonin |
UniProt Gene Name: | CALCA |
UniProt Entry Name: | CALCA_HUMAN |