CA2 Antibody, FITC conjugated (PACO25450)
- SKU:
- PACO25450
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- FITC
Description
抗体名: | CA2 Antibody, FITC conjugated (PACO25450) |
抗体コード: | PACO25450 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Carbonic anhydrase 2 protein (2-260AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | FITC |
バックグラウンド: | Essential for bone resorption and osteoclast differentiation .Reversible hydration of carbon dioxide. Can hydrate cyanamide to urea. Involved in the regulation of fluid secretion into the anterior chamber of the eye. Contributes to intracellular pH regulation in the duodenal upper villous epithelium during proton-coupled peptide absorption. Stimulates the chloride-bicarbonate exchange activity of SLC26A6. |
シノニム: | Carbonic anhydrase 2 (EC 4.2.1.1) (Carbonate dehydratase II) (Carbonic anhydrase C) (CAC) (Carbonic anhydrase II) (CA-II), CA2 |
UniProt Protein Function: | CA2: Essential for bone resorption and osteoclast differentiation. Reversible hydration of carbon dioxide. Can hydrates cyanamide to urea. Involved in the regulation of fluid secretion into the anterior chamber of the eye. Interacts with SLC4A4. Interaction with SLC4A7 regulates SLC4A7 transporter activity. Activated by X-ray, histamine, L-adrenaline, L- and D-phenylalanine, L- and D-histidine, L-His-OMe and beta-Ala- His (carnosine). Competitively inhibited by saccharin, thioxolone, coumarins, 667-coumate, celecoxib (Celebrex), valdecoxib (Bextra), SC-125, SC-560, diclofenac, acetate, azide, bromide, sulfonamide derivatives such as acetazolamide (AZA), methazolamide (MZA), ethoxzolamide (EZA), dichlorophenamide (DCP), brinzolamide, dansylamide, thiabendazole-5-sulfonamide, trifluoromethane sulfonamide and N-hydroxysulfamide, fructose-based sugar sulfamate RWJ-37497, and Foscarnet (phosphonoformate trisodium salt). Repressed strongly by hydrogen sulfide(HS) and weakly by nitrate (NO(3)). Esterase activity weakly reduced by cyanamide. N- hydroxyurea interfers with zinc binding and inhibit activity. Belongs to the alpha-carbonic anhydrase family. |
UniProt Protein Details: | Protein type:Lyase; EC 4.2.1.1; Energy Metabolism - nitrogen Chromosomal Location of Human Ortholog: 8q22 Cellular Component: extracellular space; microvillus; apical part of cell; axon; basolateral plasma membrane; cytoplasm; plasma membrane; cytosol; myelin sheath Molecular Function:protein binding; carbonate dehydratase activity; zinc ion binding Biological Process: secretion; positive regulation of osteoclast differentiation; positive regulation of synaptic transmission, GABAergic; positive regulation of cellular pH reduction; one-carbon compound metabolic process; odontogenesis of dentine-containing teeth; response to zinc ion; bicarbonate transport; response to estrogen stimulus; regulation of intracellular pH; positive regulation of bone resorption; morphogenesis of an epithelium; kidney development; response to pH Disease: Osteopetrosis, Autosomal Recessive 3 |
NCBI Summary: | The protein encoded by this gene is one of several isozymes of carbonic anhydrase, which catalyzes reversible hydration of carbon dioxide. Defects in this enzyme are associated with osteopetrosis and renal tubular acidosis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2014] |
UniProt Code: | P00918 |
NCBI GenInfo Identifier: | 115456 |
NCBI Gene ID: | 760 |
NCBI Accession: | P00918.2 |
UniProt Secondary Accession: | P00918,Q6FI12, Q96ET9, B2R7G8, |
UniProt Related Accession: | P00918 |
Molecular Weight: | 260 |
NCBI Full Name: | Carbonic anhydrase 2 |
NCBI Synonym Full Names: | carbonic anhydrase II |
NCBI Official Symbol: | CA2 |
NCBI Official Synonym Symbols: | CAC; CAII; Car2; CA-II; HEL-76 |
NCBI Protein Information: | carbonic anhydrase 2; carbonic anhydrase B; carbonic anhydrase C; carbonic dehydratase; carbonate dehydratase II; epididymis luminal protein 76 |
UniProt Protein Name: | Carbonic anhydrase 2 |
UniProt Synonym Protein Names: | Carbonate dehydratase II; Carbonic anhydrase C; CAC; Carbonic anhydrase II; CA-II |
Protein Family: | Beta-carotene hydroxylase |
UniProt Gene Name: | CA2 |
UniProt Entry Name: | CAH2_HUMAN |