C5AR2 Antibody, Biotin conjugated (PACO62102)
- SKU:
- PACO62102
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- Biotin
Frequently bought together:
Description
抗体名: | C5AR2 Antibody, Biotin conjugated (PACO62102) |
抗体コード: | PACO62102 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Peptide sequence from Human C5a anaphylatoxin chemotactic receptor 2 protein (2-19AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | Antigen Affinity Purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Biotin |
バックグラウンド: | Receptor for the chemotactic and inflammatory C3a, C4a and C5a anaphylatoxin peptides and also for their dearginated forms ASP/C3adesArg, C4adesArg and C5adesArg respectively. Couples weakly to G(i)-mediated signaling pathways. |
シノニム: | C5a anaphylatoxin chemotactic receptor 2 (Complement component 5a receptor 2) (G-protein coupled receptor 77), C5AR2, C5L2 GPR77 |
UniProt Protein Function: | C5AR2: Receptor for the chemotactic and inflammatory C3a, C4a and C5a anaphylatoxin peptides and also for their dearginated forms ASP/C3adesArg, C4adesArg and C5adesArg respectively. Couples weakly to G(i)-mediated signaling pathways. Belongs to the G-protein coupled receptor 1 family. |
UniProt Protein Details: | Protein type:GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Chromosomal Location of Human Ortholog: 19q13.32 Cellular Component: apical part of cell; basal plasma membrane; integral to plasma membrane; plasma membrane Molecular Function:complement component C5a receptor activity; G-protein coupled receptor activity; protein binding Biological Process: elevation of cytosolic calcium ion concentration; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); inflammatory response; negative regulation of tumor necrosis factor production; regulation of complement activation |
NCBI Summary: | This gene encodes a G-protein coupled receptor 1 family member involved in the complement system of the innate immune response. Unlike classical G-protein coupled receptors, the encoded protein does not associate with intracellular G-proteins. It may instead modulate signal transduction through the beta-arrestin pathway, and may alternatively act as a decoy receptor. This gene may be involved in coronary artery disease and in the pathogenesis of sepsis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012] |
UniProt Code: | Q9P296 |
NCBI GenInfo Identifier: | 20137533 |
NCBI Gene ID: | 27202 |
NCBI Accession: | Q9P296.1 |
UniProt Secondary Accession: | Q9P296,B2RA09, |
UniProt Related Accession: | Q9P296 |
Molecular Weight: | Calculated: 36 kDaObserved: 36 kDa |
NCBI Full Name: | C5a anaphylatoxin chemotactic receptor 2 |
NCBI Synonym Full Names: | complement component 5a receptor 2 |
NCBI Official Symbol: | C5AR2 |
NCBI Official Synonym Symbols: | C5L2; GPF77; GPR77 |
NCBI Protein Information: | C5a anaphylatoxin chemotactic receptor 2 |
UniProt Protein Name: | C5a anaphylatoxin chemotactic receptor 2 |
UniProt Synonym Protein Names: | Complement component 5a receptor 2; G-protein coupled receptor 77 |
Protein Family: | C5a anaphylatoxin chemotactic receptor |
UniProt Gene Name: | C5AR2 |