BTRC Antibody, Biotin conjugated (PACO48817)
- SKU:
- PACO48817
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- Biotin
Description
抗体名: | BTRC Antibody, Biotin conjugated (PACO48817) |
抗体コード: | PACO48817 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human F-box/WD repeat-containing protein 1A protein (397-448AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Biotin |
バックグラウンド: | Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds to phosphorylated target proteins. SCF(BTRC) mediates the ubiquitination of CTNNB1 and participates in Wnt signaling. SCF(BTRC) mediates the ubiquitination of NFKBIA, NFKBIB and NFKBIE; the degradation frees the associated NFKB1 to translocate into the nucleus and to activate transcription. Ubiquitination of NFKBIA occurs at 'Lys-21' and 'Lys-22'. SCF(BTRC) mediates the ubiquitination of CEP68; this is required for centriole separation during mitosis. SCF(BTRC) mediates the ubiquitination of phosphorylated NFKB1/nuclear factor NF-kappa-B p105 subunit, ATF4, CDC25A, DLG1, FBXO5, PER1, SMAD3, SMAD4, SNAI1 and probably NFKB2. Has an essential role in the control of the clock-dependent transcription via degradation of phosphorylated PER1 and PER2. May be involved in ubiquitination and subsequent proteasomal degradation through a DBB1-CUL4 E3 ubiquitin-protein ligase. Required for activation of NFKB-mediated transcription by IL1B, MAP3K14, MAP3K1, IKBKB and TNF. Required for proteolytic processing of GLI3. |
シノニム: | F-box/WD repeat-containing protein 1A (E3RSIkappaB) (Epididymis tissue protein Li 2a) (F-box and WD repeats protein beta-TrCP) (pIkappaBalpha-E3 receptor subunit), BTRC, BTRCP FBW1A FBXW1A |
UniProt Protein Function: | BTRC: a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. Regulates the stability of CTNNB1 and participates in Wnt signaling. Interacts directly with SKP1 in the SCF complex. Interacts specifically with phosphorylated CTNNB1 and NFKBIA, ubiquitination substrates. Two alternatively spliced isoforms have been described. |
UniProt Protein Details: | Protein type:Ubiquitin conjugating system; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 10q24.32 Cellular Component: nucleoplasm; SCF ubiquitin ligase complex; cytosol Molecular Function:protein dimerization activity; protein phosphorylated amino acid binding; protein binding; ubiquitin-protein ligase activity; beta-catenin binding; ligase activity Biological Process: ubiquitin-dependent protein catabolic process; positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; circadian rhythm; proteasomal ubiquitin-dependent protein catabolic process; protein polyubiquitination; viral reproduction; regulation of cell cycle; positive regulation of proteolysis; positive regulation of transcription, DNA-dependent; protein ubiquitination; positive regulation of circadian rhythm; protein amino acid dephosphorylation; signal transduction; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; G2/M transition of mitotic cell cycle; regulation of I-kappaB kinase/NF-kappaB cascade; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; Wnt receptor signaling pathway; protein destabilization; negative regulation of transcription factor activity; mammary gland epithelial cell proliferation; regulation of circadian rhythm; regulation of ubiquitin-protein ligase activity during mitotic cell cycle; negative regulation of smoothened signaling pathway; mitotic cell cycle; negative regulation of transcription, DNA-dependent |
NCBI Summary: | This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class; in addition to an F-box, this protein contains multiple WD-40 repeats. The encoded protein mediates degradation of CD4 via its interaction with HIV-1 Vpu. It has also been shown to ubiquitinate phosphorylated NFKBIA (nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha), targeting it for degradation and thus activating nuclear factor kappa-B. Alternatively spliced transcript variants have been described. A related pseudogene exists in chromosome 6. [provided by RefSeq, Mar 2012] |
UniProt Code: | Q9Y297 |
NCBI GenInfo Identifier: | 13124271 |
NCBI Gene ID: | 8945 |
NCBI Accession: | Q9Y297.1 |
UniProt Secondary Accession: | Q9Y297,Q5W141, Q5W142, Q9Y213, B5MD49, |
UniProt Related Accession: | Q9Y297 |
Molecular Weight: | 605 |
NCBI Full Name: | F-box/WD repeat-containing protein 1A |
NCBI Synonym Full Names: | beta-transducin repeat containing E3 ubiquitin protein ligase |
NCBI Official Symbol: | BTRC |
NCBI Official Synonym Symbols: | FWD1; FBW1A; FBXW1; bTrCP; FBXW1A; bTrCP1; betaTrCP; BETA-TRCP |
NCBI Protein Information: | F-box/WD repeat-containing protein 1A; beta-TrCP1; E3RSIkappaB; F-box and WD-repeat protein 1B; epididymis tissue protein Li 2a; pIkappaBalpha-E3 receptor subunit; F-box and WD repeats protein beta-TrCP |
UniProt Protein Name: | F-box/WD repeat-containing protein 1A |
UniProt Synonym Protein Names: | E3RSIkappaB; Epididymis tissue protein Li 2a; F-box and WD repeats protein beta-TrCP; pIkappaBalpha-E3 receptor subunit |
Protein Family: | F-box/WD repeat-containing protein |
UniProt Gene Name: | BTRC |
UniProt Entry Name: | FBW1A_HUMAN |