BRSK1 Antibody, Biotin conjugated (PACO49245)
- SKU:
- PACO49245
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- Biotin
Description
抗体名: | BRSK1 Antibody, Biotin conjugated (PACO49245) |
抗体コード: | PACO49245 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Serine/threonine-protein kinase BRSK1 protein (426-591AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Biotin |
バックグラウンド: | Serine/threonine-protein kinase that plays a key role in polarization of neurons and centrosome duplication. Phosphorylates CDC25B, CDC25C, MAPT/TAU, RIMS1, TUBG1, TUBG2 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Thr-529' and 'Ser-579'. Also regulates neuron polarization by mediating phosphorylation of WEE1 at 'Ser-642' in post-mitotic neurons, leading to down-regulate WEE1 activity in polarized neurons. In neurons, localizes to synaptic vesicles and plays a role in neurotransmitter release, possibly by phosphorylating RIMS1. Also acts as a positive regulator of centrosome duplication by mediating phosphorylation of gamma-tubulin (TUBG1 and TUBG2) at 'Ser-131', leading to translocation of gamma-tubulin and its associated proteins to the centrosome. Involved in the UV-induced DNA damage checkpoint response, probably by inhibiting CDK1 activity through phosphorylation and activation of WEE1, and inhibition of CDC25B and CDC25C. |
シノニム: | Serine/threonine-protein kinase BRSK1 (EC 2.7.11.1) (Brain-selective kinase 1) (EC 2.7.11.26) (Brain-specific serine/threonine-protein kinase 1) (BR serine/threonine-protein kinase 1) (Serine/threonine-protein kinase SAD-B) (Synapses of Amphids Defective homolog 1) (SAD1 homolog) (hSAD1), BRSK1, KIAA1811 SAD1 SADB |
UniProt Protein Function: | BRSK1: a serine/threonine protein kinase of the CAMK group. Closely related to AMPK. Activated by the kinase LKB1. Acts as checkpoint kinase upon DNA damage induced by UV or methyl methane sulfonate. Phosphorylates WEE1 and CDC25B in vitro and CDC25C in vitro and in vivo. Translocates from the cytoplasm to the nucleus in response to UV- or MMS-induced DNA damage. BRSK1 and BRSK2 are required for neuronal polarization. Widely expressed with highest levels in the brain and testis. Two alternatively spliced isoforms have been described. |
UniProt Protein Details: | Protein type:Protein kinase, Ser/Thr (non-receptor); Protein kinase, CAMK; Kinase, protein; EC 2.7.11.26; EC 2.7.11.1; CAMK group; CAMKL family; BRSK subfamily Chromosomal Location of Human Ortholog: 19q13.4 Cellular Component: nucleoplasm; centrosome; synaptic vesicle; cytoplasm; cell junction; nucleus Molecular Function:protein serine/threonine kinase activity; gamma-tubulin binding; tau-protein kinase activity; magnesium ion binding; protein kinase binding; ATP binding Biological Process: neuron differentiation; axonogenesis; establishment of cell polarity; neurotransmitter secretion; response to ionizing radiation; G2/M transition DNA damage checkpoint; centrosome duplication; response to DNA damage stimulus; protein amino acid phosphorylation; response to UV |
UniProt Code: | Q8TDC3 |
NCBI GenInfo Identifier: | 34395684 |
NCBI Gene ID: | 84446 |
NCBI Accession: | Q8TDC3.1 |
UniProt Secondary Accession: | Q8TDC3,Q5J5B5, Q8NDD0, Q8NDR4, Q8TDC2, Q96AV4, Q96JL4 F1DG44, |
UniProt Related Accession: | Q8TDC3 |
Molecular Weight: | 38,782 Da |
NCBI Full Name: | BR serine/threonine-protein kinase 1 |
NCBI Synonym Full Names: | BR serine/threonine kinase 1 |
NCBI Official Symbol: | BRSK1 |
NCBI Official Synonym Symbols: | hSAD1 |
NCBI Protein Information: | serine/threonine-protein kinase BRSK1; SAD1 kinase; SAD1 homolog; protein kinase SAD1A; brain-selective kinase 1; SadB kinase short isoform; BR serine/threonine-protein kinase 1; serine/threonine-protein kinase SAD-B; synapses of Amphids Defective homolog 1; brain-specific serine/threonine-protein kinase 1 |
UniProt Protein Name: | Serine/threonine-protein kinase BRSK1 |
UniProt Synonym Protein Names: | Brain-selective kinase 1 (EC:2.7.11.26); Brain-specific serine/threonine-protein kinase 1; BR serine/threonine-protein kinase 1; Serine/threonine-protein kinase SAD-B; Synapses of Amphids Defective homolog 1; SAD1 homolog; hSAD1 |
Protein Family: | Serine/threonine-protein kinase |
UniProt Gene Name: | BRSK1 |
UniProt Entry Name: | BRSK1_HUMAN |