BMP10 Antibody (PACO07254)
- SKU:
- PACO07254
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | BMP10 Antibody (PACO07254) |
抗体コード: | PACO07254 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, WB |
推奨される希釈: | ELISA:1:10000-1:20000, WB:1:500-1:2000 |
反応性: | Human, Mouse, Rat |
免疫原: | Synthesized peptide derived from BMP-10 at AA range: 361-410 |
憲法: | Liquid |
ストレージバッファ: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
精製方法: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
![]() | Western Blot analysis of mouse-brain mouse-lung cells using BMP-10 Polyclonal Antibody diluted at 1:1000. Secondary antibody was diluted at 1:20000. |
シノニム: | bone morphogenetic protein 10 |
UniProt Protein Function: | Required for maintaining the proliferative activity of embryonic cardiomyocytes by preventing premature activation of the negative cell cycle regulator CDKN1C/p57KIP and maintaining the required expression levels of cardiogenic factors such as MEF2C and NKX2-5. Acts as a ligand for ACVRL1/ALK1, BMPR1A/ALK3 and BMPR1B/ALK6, leading to activation of SMAD1, SMAD5 and SMAD8 transcription factors. Inhibits endothelial cell migration and growth. May reduce cell migration and cell matrix adhesion in breast cancer cell lines. |
NCBI Summary: | This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate the mature protein, which binds to the activin receptor-like kinase 1 (ALK1) and plays important roles in cardiovascular development including cardiomyocyte proliferation and regulation of heart size, closure of the ductus arteriosus, angiogenesis and ventricular trabeculation. [provided by RefSeq, Aug 2016] |
UniProt Code: | O95393 |
NCBI GenInfo Identifier: | 13123977 |
NCBI Gene ID: | 27302 |
NCBI Accession: | O95393.1 |
UniProt Secondary Accession: | O95393,Q53R17, Q6NTE0, |
UniProt Related Accession: | O95393 |
Molecular Weight: | 48,047 Da |
NCBI Full Name: | Bone morphogenetic protein 10 |
NCBI Synonym Full Names: | bone morphogenetic protein 10 |
NCBI Official Symbol: | BMP10 |
NCBI Protein Information: | bone morphogenetic protein 10 |
UniProt Protein Name: | Bone morphogenetic protein 10 |
Protein Family: | Bone morphogenetic protein |
UniProt Gene Name: | BMP10 |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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