BLOC1S1 Antibody (PACO25632)
- SKU:
- PACO25632
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | BLOC1S1 Antibody (PACO25632) |
抗体コード: | PACO25632 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC, IF |
推奨される希釈: | ELISA:1:2000-1:10000, WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:200 |
反応性: | Human |
免疫原: | Recombinant Human Biogenesis of lysosome-related organelles complex 1 subunit 1 protein (1-153AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
![]() | Western blot All lanes: BLOC1S1 antibody at 2µg/ml Lane 1: EC109 whole cell lysate Lane 2: 293T whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/15000 dilution Predicted band size: 18, 15 kDa Observed band size: 75 kDa . |
![]() | Immunohistochemistry of paraffin-embedded human small intestine tissue using PACO25632 at dilution of 1:100. |
![]() | Immunofluorescent analysis of HepG2 cells using PACO25632 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
シノニム: | Biogenesis of lysosome-related organelles complex 1 subunit 1 (BLOC-1 subunit 1) (GCN5-like protein 1) (Protein RT14), BLOC1S1, BLOS1 GCN5L1 RT14 |
UniProt Protein Function: | BLOC1S1: May negatively regulate aerobic respiration through mitochondrial protein lysine-acetylation. May counteract the action of the deacetylase SIRT3 by acetylating and regulating proteins of the mitochondrial respiratory chain including ATP5A1 AND NDUFA9. May also be involved in the biogenesis of specialized organelles of the endosomal-lysosomal system. Belongs to the BLOC1S1 family. 2 isoforms of the human protein are produced by alternative initiation. |
UniProt Protein Details: | Protein type:Nuclear receptor co-regulator; Vesicle Chromosomal Location of Human Ortholog: 12q13-q14 Cellular Component: extracellular space; lysosomal membrane; mitochondrial matrix; mitochondrial intermembrane space; cytosol Molecular Function:protein binding Biological Process: platelet dense granule organization and biogenesis; melanosome organization and biogenesis; anterograde synaptic vesicle transport; aerobic respiration; post-Golgi vesicle-mediated transport; anterograde axon cargo transport; peptidyl-lysine acetylation; neurite development |
NCBI Summary: | BLOC1S1 is a component of the ubiquitously expressed BLOC1 multisubunit protein complex. BLOC1 is required for normal biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules (Starcevic and Dell'Angelica, 2004 [PubMed 15102850]).[supplied by OMIM, Mar 2008] |
UniProt Code: | P78537 |
NCBI GenInfo Identifier: | 332278161 |
NCBI Gene ID: | 2647 |
NCBI Accession: | P78537.2 |
UniProt Secondary Accession: | P78537,Q6NZ45, A1L4Q9, |
UniProt Related Accession: | P78537 |
Molecular Weight: | 153 |
NCBI Full Name: | Biogenesis of lysosome-related organelles complex 1 subunit 1 |
NCBI Synonym Full Names: | biogenesis of lysosomal organelles complex-1, subunit 1 |
NCBI Official Symbol: | BLOC1S1 |
NCBI Official Synonym Symbols: | RT14; BLOS1; MICoA; GCN5L1 |
NCBI Protein Information: | biogenesis of lysosome-related organelles complex 1 subunit 1; BLOC subunit 1; BLOC-1 subunit 1; GCN5-like protein 1; MTA1-interacting coactivator; GCN5 general control of amino-acid synthesis 5-like 1; GCN5 (general control of amino-acid synthesis, yeast, homolog)-like 1 |
UniProt Protein Name: | Biogenesis of lysosome-related organelles complex 1 subunit 1 |
UniProt Synonym Protein Names: | GCN5-like protein 1; Protein RT14 |
Protein Family: | Biogenesis of lysosome-related organelles complex |
UniProt Gene Name: | BLOC1S1 |
UniProt Entry Name: | BL1S1_HUMAN |