BLMH Antibody (PACO42988)
- SKU:
- PACO42988
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | BLMH Antibody (PACO42988) |
抗体コード: | PACO42988 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, IHC |
推奨される希釈: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
反応性: | Human |
免疫原: | Recombinant Human Bleomycin hydrolase protein (1-300AA) |
憲法: | Liquid |
ストレージバッファ: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
精製方法: | Antigen Affinity Purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
![]() | Immunohistochemistry of paraffin-embedded human colon cancer using PACO42988 at dilution of 1:100. |
バックグラウンド: | The normal physiological role of BLM hydrolase is unknown, but it catalyzes the inactivation of the antitumor drug BLM (a glycopeptide) by hydrolyzing the carboxamide bond of its B-aminoalaninamide moiety thus protecting normal and malignant cells from BLM toxicity. |
シノニム: | Bleomycin hydrolase (BH) (BLM hydrolase) (BMH) (EC 3.4.22.40), BLMH |
UniProt Protein Function: | BLMH: The normal physiological role of BLM hydrolase is unknown, but it catalyzes the inactivation of the antitumor drug BLM (a glycopeptide) by hydrolyzing the carboxamide bond of its B- aminoalaninamide moiety thus protecting normal and malignant cells from BLM toxicity. Belongs to the peptidase C1 family. |
UniProt Protein Details: | Protein type:EC 3.4.22.40; Protease Chromosomal Location of Human Ortholog: 17q11.2 Cellular Component: cytoplasm; cytosol; nucleus Molecular Function:aminopeptidase activity; carboxypeptidase activity; cysteine-type peptidase activity; protein binding Biological Process: protein polyubiquitination Disease: Alzheimer Disease |
NCBI Summary: | Bleomycin hydrolase (BMH) is a cytoplasmic cysteine peptidase that is highly conserved through evolution; however, the only known activity of the enzyme is metabolic inactivation of the glycopeptide bleomycin (BLM), an essential component of combination chemotherapy regimens for cancer. The protein contains the signature active site residues of the cysteine protease papain superfamily. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q13867 |
NCBI GenInfo Identifier: | 3023394 |
NCBI Gene ID: | 642 |
NCBI Accession: | Q13867.1 |
UniProt Secondary Accession: | Q13867,Q53F86, Q9UER9, B2R796, |
UniProt Related Accession: | Q13867 |
Molecular Weight: | 52,562 Da |
NCBI Full Name: | Bleomycin hydrolase |
NCBI Synonym Full Names: | bleomycin hydrolase |
NCBI Official Symbol: | BLMH |
NCBI Official Synonym Symbols: | BH; BMH |
NCBI Protein Information: | bleomycin hydrolase |
UniProt Protein Name: | Bleomycin hydrolase |
Protein Family: | Bleomycin hydrolase |
UniProt Gene Name: | BLMH |
UniProt Entry Name: | BLMH_HUMAN |