BCAP31 Antibody (PACO31676)
- SKU:
- PACO31676
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Application:
- IF
- Application:
- IP
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
抗体名: | BCAP31 Antibody (PACO31676) |
抗体コード: | PACO31676 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC, IF, IP |
推奨される希釈: | ELISA:1:2000-1:10000, WB:1:1000-1:5000, IHC:1:1000-1:2000, IF:1:200-1:500, IP:1:200-1:2000, |
反応性: | Human, Mouse, Rat |
免疫原: | Recombinant Human B-cell receptor-associated protein 31 protein (2-243AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
Western Blot Positive WB detected in: 293 whole cell lysate, Hela whole cell lysate, MCF-7 whole cell lysate, SH-SY5Y whole cell lysate, Rat lung tissue, Rat brain tissue, Mouse lung tissue, Mouse brain tissue All lanes: BCAP31 antibody at 4.8µg/ml Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 28, 35 kDa Observed band size: 28 kDa . | |
IHC image of PACO31676 diluted at 1:1200 and staining in paraffin-embedded human prostate cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. | |
IHC image of PACO31676 diluted at 1:1200 and staining in paraffin-embedded human colon cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
バックグラウンド: | Functions as a chaperone protein. Is one of the most abundant endoplasmic reticulum (ER) proteins. Plays a role in the export of secreted proteins in the ER, the recognition of abnormally folded protein and their targeting to the ER associated-degradation (ERAD). Also serves as a cargo receptor for the export of transmembrane proteins. May be involved in CASP8-mediated apoptosis. |
シノニム: | B-cell receptor-associated protein 31 (BCR-associated protein 31) (Bap31) (6C6-AG tumor-associated antigen) (Protein CDM) (p28), BCAP31, BAP31 DXS1357E |
UniProt Protein Function: | BCAP31 iso2: May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi. May be involved in CASP8-mediated apoptosis. Homodimer and heterodimer with BCAP29. Binds CASP8 (isoform 9) as a complex containing BCAP31, BCAP29, BCL2 and/or BCL2L1. Interacts with VAMP3, VAMP1 and membrane IgD immunoglobulins. May interact with ACTG1 and non-muscle myosin II. Interacts with PTPLB. Ubiquitous. Belongs to the BCAP29/BCAP31 family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Membrane protein, integral; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: Xq28 Cellular Component: endoplasmic reticulum membrane; ER-Golgi intermediate compartment membrane; membrane; clathrin-coated vesicle; endoplasmic reticulum; integral to plasma membrane; lipid particle; cytosol Molecular Function:protein binding; MHC class I protein binding; protein complex binding Biological Process: intracellular protein transport; ER to Golgi vesicle-mediated transport; antigen processing and presentation of peptide antigen via MHC class I; elevation of cytosolic calcium ion concentration; apoptosis; reduction of endoplasmic reticulum calcium ion concentration; positive regulation of caspase activity; spermatogenesis; cell structure disassembly during apoptosis; elevation of mitochondrial calcium ion concentration Disease: Deafness, Dystonia, And Cerebral Hypomyelination |
NCBI Summary: | This gene encodes a member of the B-cell receptor associated protein 31 superfamily. The encoded protein is a multi-pass transmembrane protein of the endoplasmic reticulum that is involved in the anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi and in caspase 8-mediated apoptosis. Microdeletions in this gene are associated with contiguous ABCD1/DXS1375E deletion syndrome (CADDS), a neonatal disorder. Alternative splicing of this gene results in multiple transcript variants. Two related pseudogenes have been identified on chromosome 16. [provided by RefSeq, Jan 2012] |
UniProt Code: | P51572 |
NCBI GenInfo Identifier: | 1705725 |
NCBI Gene ID: | 10134 |
NCBI Accession: | P51572.3 |
UniProt Secondary Accession: | P51572,Q13836, Q96CF0, B3KQ79, D3DWV5, |
UniProt Related Accession: | P51572 |
Molecular Weight: | 34,752 Da |
NCBI Full Name: | B-cell receptor-associated protein 31 |
NCBI Synonym Full Names: | B-cell receptor-associated protein 31 |
NCBI Official Symbol: | BCAP31 |
NCBI Official Synonym Symbols: | CDM; DDCH; BAP31; 6C6-AG; DXS1357E |
NCBI Protein Information: | B-cell receptor-associated protein 31; p28 Bap31; BCR-associated protein Bap31; 6C6-AG tumor-associated antigen |
UniProt Protein Name: | B-cell receptor-associated protein 31 |
UniProt Synonym Protein Names: | 6C6-AG tumor-associated antigen; Protein CDM; p28 |
Protein Family: | B-cell receptor-associated protein |
UniProt Gene Name: | BCAP31 |
UniProt Entry Name: | BAP31_HUMAN |
Antibodies | ELISA Kits |
Anti-BCAP31 Antibody (CAB7056) | Human B-cell receptor-associated protein 31 (BCAP31) ELISA Kit |
BCAP31 Antibody (PACO06277) | |
BCAP31 Antibody (PACO07984) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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