BACE2 Antibody, Biotin conjugated (PACO51233)
- SKU:
- PACO51233
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- Biotin
Frequently bought together:
Description
抗体名: | BACE2 Antibody, Biotin conjugated (PACO51233) |
抗体コード: | PACO51233 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Beta-secretase 2 protein (84-157AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Biotin |
バックグラウンド: | Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves APP, between residues 690 and 691, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. It has also been shown that it can cleave APP between residues 671 and 672. |
シノニム: | Beta-secretase 2 (EC 3.4.23.45) (Aspartic-like protease 56 kDa) (Aspartyl protease 1) (ASP1) (Asp 1) (Beta-site amyloid precursor protein cleaving enzyme 2) (Beta-site APP cleaving enzyme 2) (Down region aspartic protease) (DRAP) (Memapsin-1) (Membrane-associated aspartic protease 1) (Theta-secretase), BACE2, AEPLC ALP56 ASP21 |
UniProt Protein Function: | BACE2: Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves APP, between residues 690 and 691, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C- terminal fragment which is later released by gamma-secretase. It has also been shown that it can cleave APP between residues 671 and 672. Belongs to the peptidase A1 family. 5 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:EC 3.4.23.45; Protease; Membrane protein, integral Chromosomal Location of Human Ortholog: 21q22.3 Cellular Component: Golgi apparatus; cell surface; endoplasmic reticulum; integral to membrane; endosome Molecular Function:aspartic-type endopeptidase activity Biological Process: negative regulation of amyloid precursor protein biosynthetic process; membrane protein ectodomain proteolysis; peptide hormone processing; proteolysis |
NCBI Summary: | This gene encodes an integral membrane glycoprotein that functions as an aspartic protease. The encoded protein cleaves amyloid precursor protein into amyloid beta peptide, which is a critical step in the etiology of Alzheimer's disease and Down syndrome. The protein precursor is further processed into an active mature peptide. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013] |
UniProt Code: | Q9Y5Z0 |
NCBI GenInfo Identifier: | 6685260 |
NCBI Gene ID: | 25825 |
NCBI Accession: | Q9Y5Z0.1 |
UniProt Secondary Accession: | Q9Y5Z0,Q5DIH8, Q8N2D4, Q9H2V8, Q9NZL1, Q9NZL2, Q9UJT6 A8K7P1, |
UniProt Related Accession: | Q9Y5Z0 |
Molecular Weight: | 518 |
NCBI Full Name: | Beta-secretase 2 |
NCBI Synonym Full Names: | beta-site APP-cleaving enzyme 2 |
NCBI Official Symbol: | BACE2 |
NCBI Official Synonym Symbols: | ASP1; BAE2; DRAP; AEPLC; ALP56; ASP21; CDA13; CEAP1 |
NCBI Protein Information: | beta-secretase 2; memapsin-1; theta-secretase; aspartyl protease 1; 56 kDa aspartic-like protease; Down syndrome region aspartic protease; transmembrane aspartic proteinase Asp1; membrane-associated aspartic protease 1; beta-site amyloid beta A4 precursor protein-cleaving enzyme 2 |
UniProt Protein Name: | Beta-secretase 2 |
UniProt Synonym Protein Names: | Aspartic-like protease 56 kDa; Aspartyl protease 1; ASP1; Asp 1; Beta-site amyloid precursor protein cleaving enzyme 2; Beta-site APP cleaving enzyme 2; Down region aspartic protease; DRAP; Memapsin-1; Membrane-associated aspartic protease 1; Theta-secretase |
Protein Family: | Beta-secretase |
UniProt Gene Name: | BACE2 |
UniProt Entry Name: | BACE2_HUMAN |