B4GAT1 Antibody, HRP conjugated (PACO25189)
- SKU:
- PACO25189
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- HRP
Frequently bought together:
Description
抗体名: | B4GAT1 Antibody, HRP conjugated (PACO25189) |
抗体コード: | PACO25189 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Beta-1,4-glucuronyltransferase 1 protein (161-415AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | HRP |
バックグラウンド: | Beta-1,4-glucuronyltransferase involved in O-mannosylation of alpha-dystroglycan (DAG1). Transfers a glucuronic acid, (GlcA) residue onto a xylose (Xyl) acceptor to produce the glucuronyl-beta-1,4-xylose-β disaccharide primer, which is further elongated by LARGE, during synthesis of phosphorylated O-mannosyl glycan (PubMed:25279699, PubMed:25279697). Phosphorylated O-mannosyl glycan is a carbohydrate is a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity (PubMed:25279699, PubMed:25279697). Required for axon guidance; via its function in O-mannosylation of alpha-dystroglycan (DAG1). |
シノニム: | Beta-1,4-glucuronyltransferase 1 (EC 2.4.1.-) (I-beta-1,3-N-acetylglucosaminyltransferase) (iGnT) (N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase) (Poly-N-acetyllactosamine extension enzyme) (UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1), B4GAT1, B3GNT1 B3GNT6 |
UniProt Protein Function: | B4GAT1: Can initiate the synthesis or the elongation of the linear poly-N-acetyllactosaminoglycans. |
UniProt Protein Details: | Protein type:Glycan Metabolism - glycosphingolipid biosynthesis - lacto and neolacto series; Transferase; EC 2.4.1.149; Glycan Metabolism - keratan sulfate biosynthesis; Membrane protein, integral Chromosomal Location of Human Ortholog: 11q13.2 Cellular Component: Golgi apparatus; Golgi membrane Molecular Function:glucuronosyltransferase activity; N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity Biological Process: keratan sulfate biosynthetic process; poly-N-acetyllactosamine biosynthetic process; protein amino acid O-linked mannosylation Disease: Muscular Dystrophy-dystroglycanopathy (congenital With Brain And Eye Anomalies), Type A, 13 |
NCBI Summary: | This gene encodes a member of the beta-1,3-N-acetylglucosaminyltransferase family. This enzyme is a type II transmembrane protein. It is essential for the synthesis of poly-N-acetyllactosamine, a determinant for the blood group i antigen. [provided by RefSeq, Jul 2008] |
UniProt Code: | O43505 |
NCBI GenInfo Identifier: | 23396461 |
NCBI Gene ID: | 11041 |
NCBI Accession: | O43505.1 |
UniProt Secondary Accession: | O43505,Q4TTN0, |
UniProt Related Accession: | O43505 |
Molecular Weight: | 47,119 Da |
NCBI Full Name: | Beta-1,4-glucuronyltransferase 1 |
NCBI Synonym Full Names: | beta-1,4-glucuronyltransferase 1 |
NCBI Official Symbol: | B4GAT1 |
NCBI Official Synonym Symbols: | iGAT; iGNT; B3GNT1; B3GNT6; B3GN-T1; MDDGA13; BETA3GNTI |
NCBI Protein Information: | beta-1,4-glucuronyltransferase 1 |
UniProt Protein Name: | Beta-1,4-glucuronyltransferase 1 |
UniProt Synonym Protein Names: | I-beta-1,3-N-acetylglucosaminyltransferase; iGnT; N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase; Poly-N-acetyllactosamine extension enzyme; UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1 |
UniProt Gene Name: | B4GAT1 |
UniProt Entry Name: | B4GA1_HUMAN |