B4GALT2 Antibody (PACO05610)
- SKU:
- PACO05610
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
抗体名: | B4GALT2 Antibody (PACO05610) |
抗体コード: | PACO05610 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, IHC |
推奨される希釈: | ELISA:1:20000, IHC:1:100-1:300 |
反応性: | Human, Mouse |
免疫原: | Synthesized peptide derived from the C-terminal region of human β -1,4-Gal-T2. |
憲法: | Liquid |
ストレージバッファ: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
精製方法: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
シノニム: | B4GALT2; β-1; 4-galactosyltransferase 2; β-1,4-GalTase 2; β4Gal-T2; b4Gal-T2; UDP-Gal:β-GlcNAc β-1,4-galactosyltransferase 2; UDP-galactose:β-N-acetylglucosamine β-1,4-galactosyltransferase 2 |
UniProt Protein Function: | B4GALT2: Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids. Can produce lactose. Belongs to the glycosyltransferase 7 family. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Carbohydrate Metabolism - galactose; EC 2.4.1.22; Glycan Metabolism - keratan sulfate biosynthesis; EC 2.4.1.90; Glycan Metabolism - N-glycan biosynthesis; Glycan Metabolism - glycosphingolipid biosynthesis - lacto and neolacto series; EC 2.4.1.38; Transferase; Membrane protein, integral Chromosomal Location of Human Ortholog: 1p34-p33 Cellular Component: Golgi membrane; integral to membrane Molecular Function:beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity; N-acetyllactosamine synthase activity; metal ion binding; lactose synthase activity; galactosyltransferase activity Biological Process: keratan sulfate metabolic process; cellular protein metabolic process; glycosaminoglycan metabolic process; carbohydrate metabolic process; keratan sulfate biosynthetic process; protein amino acid N-linked glycosylation via asparagine; pathogenesis; post-translational protein modification |
NCBI Summary: | This gene is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose; all transfer galactose in a beta1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. The enzyme encoded by this gene synthesizes N-acetyllactosamine in glycolipids and glycoproteins. Its substrate specificity is affected by alpha-lactalbumin but it is not expressed in lactating mammary tissue. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2011] |
UniProt Code: | O60909 |
NCBI GenInfo Identifier: | 13123972 |
NCBI Gene ID: | 8704 |
NCBI Accession: | O60909.1 |
UniProt Secondary Accession: | O60909,O60511, Q4V9L9, Q5T4X5, Q5T4Y5, Q9BUP6, Q9NSY7 B3KTP0, B4DE14, D3DPY6, D3DPY7, |
UniProt Related Accession: | O60909 |
Molecular Weight: | 44,764 Da |
NCBI Full Name: | Beta-1,4-galactosyltransferase 2 |
NCBI Synonym Full Names: | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2 |
NCBI Official Symbol: | B4GALT2 |
NCBI Official Synonym Symbols: | B4Gal-T2; B4Gal-T3; beta4Gal-T2 |
NCBI Protein Information: | beta-1,4-galactosyltransferase 2; UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 2; UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase 2; UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 2; UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 2; beta-1,4-GalTase 2; beta-4-GalT2; beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase 2 |
UniProt Protein Name: | Beta-1,4-galactosyltransferase 2 |
UniProt Synonym Protein Names: | UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 2; UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 2Including the following 4 domains:Lactose synthase A protein (EC:2.4.1.22); N-acetyllactosamine synthase (EC:2.4.1.90)Alternative name(s):Nal synthase |
Protein Family: | Beta-1,4-galactosyltransferase |
UniProt Gene Name: | B4GALT2 |
UniProt Entry Name: | B4GT2_HUMAN |