B3GNT5 Antibody, Biotin conjugated (PACO25203)
- SKU:
- PACO25203
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- Biotin
Description
抗体名: | B3GNT5 Antibody, Biotin conjugated (PACO25203) |
抗体コード: | PACO25203 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase protein (65-344AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Biotin |
バックグラウンド: | Beta-1,3-N-acetylglucosaminyltransferase that plays a key role in the synthesis of lacto- or neolacto-series carbohydrate chains on glycolipids, notably by participating in biosynthesis of HNK-1 and Lewis X carbohydrate structures. Has strong activity toward lactosylceramide (LacCer) and neolactotetraosylceramide (nLc4Cer; paragloboside), resulting in the synthesis of Lc3Cer and neolactopentaosylceramide (nLc5Cer), respectively. Probably plays a central role in regulating neolacto-series glycolipid synthesis during embryonic development. |
シノニム: | Lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase (EC 2.4.1.206) (Lactotriaosylceramide synthase) (Lc(3)Cer synthase) (Lc3 synthase) (UDP-GlcNAc:beta-Gal beta-1,3-N-acetylglucosaminyltransferase 5) (BGnT-5) (Beta-1,3-Gn-T5) (Beta-1,3-N-acetylglucosaminyltransferase 5) (Beta3Gn-T5), B3GNT5 |
UniProt Protein Function: | B3GNT5: Beta-1,3-N-acetylglucosaminyltransferase that plays a key role in the synthesis of lacto- or neolacto-series carbohydrate chains on glycolipids, notably by participating in biosynthesis of HNK-1 and Lewis X carbohydrate structures. Has strong activity toward lactosylceramide (LacCer) and neolactotetraosylceramide (nLc(4)Cer; paragloboside), resulting in the synthesis of Lc(3)Cer and neolactopentaosylceramide (nLc(5)Cer), respectively. Probably plays a central role in regulating neolacto-series glycolipid synthesis during embryonic development. Belongs to the glycosyltransferase 31 family. |
UniProt Protein Details: | Protein type:Membrane protein, integral; Transferase; Glycan Metabolism - glycosphingolipid biosynthesis - lacto and neolacto series; EC 2.4.1.206 Chromosomal Location of Human Ortholog: 3q28 Cellular Component: Golgi membrane; integral to membrane; intracellular Molecular Function:lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase activity; galactosyltransferase activity; beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity Biological Process: protein amino acid O-linked glycosylation; cellular protein metabolic process; central nervous system development; O-glycan processing; glycolipid biosynthetic process; protein amino acid glycosylation; post-translational protein modification |
NCBI Summary: | This gene encodes a member of the beta-1,3-N-acetylglucosaminyltransferase family. This enzyme is a type II membrane protein. It exhibits strong activity to transfer GlcNAc to glycolipid substrates and is identified as the most likely candidate for lactotriaosylceramide synthase. This enzyme is essential for the expression of Lewis X epitopes on glycolipids. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q9BYG0 |
NCBI GenInfo Identifier: | 74733473 |
NCBI Gene ID: | 84002 |
NCBI Accession: | Q9BYG0.1 |
UniProt Secondary Accession: | Q9BYG0,Q59FE3, Q7L9Z5, Q8WWP9, D3DNS5, |
UniProt Related Accession: | Q9BYG0 |
Molecular Weight: | 378 |
NCBI Full Name: | Lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase |
NCBI Synonym Full Names: | UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5 |
NCBI Official Symbol: | B3GNT5 |
NCBI Official Synonym Symbols: | B3GN-T5; beta3Gn-T5 |
NCBI Protein Information: | lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase; BGnT-5; lc3 synthase; beta-1,3-Gn-T5; lc(3)Cer synthase; lactotriaosylceramide synthase; beta-1,3-N-acetylglucosaminyltransferase 5; beta-1,3-N-acetylglucosaminyltransferase bGnT-5; beta 1,3 N-acetyglucosaminyltransferase Lc3 synthase; UDP-GlcNAc:beta-Gal beta-1,3-N-acetylglucosaminyltransferase 5 |
UniProt Protein Name: | Lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase |
UniProt Synonym Protein Names: | Lactotriaosylceramide synthase; Lc(3)Cer synthase; Lc3 synthase; UDP-GlcNAc:beta-Gal beta-1,3-N-acetylglucosaminyltransferase 5; BGnT-5; Beta-1,3-Gn-T5; Beta-1,3-N-acetylglucosaminyltransferase 5; Beta3Gn-T5 |
Protein Family: | Lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase |
UniProt Gene Name: | B3GNT5 |
UniProt Entry Name: | B3GN5_HUMAN |