UniProt Protein Function: | B3GAT1: Involved in the biosynthesis of L2/HNK-1 carbohydrate epitope on glycoproteins. Can also play a role in glycosaminoglycan biosynthesis. Substrates include asialo- orosomucoid (ASOR), asialo-fetuin, and asialo-neural cell adhesion molecule. Requires sphingomyelin for activity: stearoyl- sphingomyelin was the most effective, followed by palmitoyl- sphingomyelin and lignoceroyl-sphingomyelin. Activity was demonstrated only for sphingomyelin with a saturated fatty acid and not for that with an unsaturated fatty acid, regardless of the length of the acyl group. Belongs to the glycosyltransferase 43 family. |
UniProt Protein Details: | Protein type:EC 2.4.1.135; Glycan Metabolism - chondroitin sulfate biosynthesis; Transferase; Membrane protein, integral; Glycan Metabolism - heparan sulfate biosynthesis Chromosomal Location of Human Ortholog: 11q25 Cellular Component: Golgi membrane Molecular Function:galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity Biological Process: carbohydrate metabolic process; chondroitin sulfate metabolic process; chondroitin sulfate proteoglycan biosynthetic process; glycosaminoglycan metabolic process |
NCBI Summary: | The protein encoded by this gene is a member of the glucuronyltransferase gene family. These enzymes exhibit strict acceptor specificity, recognizing nonreducing terminal sugars and their anomeric linkages. This gene product functions as the key enzyme in a glucuronyl transfer reaction during the biosynthesis of the carbohydrate epitope HNK-1 (human natural killer-1, also known as CD57 and LEU7). Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q9P2W7 |
NCBI GenInfo Identifier: | 205830910 |
NCBI Gene ID: | 27087 |
NCBI Accession: | Q9P2W7.2 |
UniProt Secondary Accession: | Q9P2W7,Q96FS7, |
UniProt Related Accession: | Q9P2W7 |
Molecular Weight: | 38,256 Da |
NCBI Full Name: | Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1 |
NCBI Synonym Full Names: | beta-1,3-glucuronyltransferase 1 |
NCBI Official Symbol: | B3GAT1 |
NCBI Official Synonym Symbols: | NK1; CD57; HNK1; LEU7; NK-1; GLCATP; GLCUATP |
NCBI Protein Information: | galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1 |
UniProt Protein Name: | Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1 |
UniProt Synonym Protein Names: | Beta-1,3-glucuronyltransferase 1; Glucuronosyltransferase P; GlcAT-P; UDP-GlcUA:glycoprotein beta-1,3-glucuronyltransferase; GlcUAT-P |
Protein Family: | Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase |
UniProt Gene Name: | B3GAT1 |
UniProt Entry Name: | B3GA1_HUMAN |