B2M Antibody, FITC conjugated (PACO32030)
- SKU:
- PACO32030
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- FITC
Description
抗体名: | B2M Antibody, FITC conjugated (PACO32030) |
抗体コード: | PACO32030 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Beta-2-microglobulin protein (22-119AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | FITC |
バックグラウンド: | β 2 Microglobulin non-covalently associates with the 44 kDa α chain to form the HLA Class I antigen complex. Human β 2 Microglobulin associated with HLA Class I antigens are expressed on many types of cells including lymphocytes, thymocytes, monocytes, granulocytes, platelets, endothelial cells, and epithelial cells. It is absent on erythrocytes. |
シノニム: | Beta-2-microglobulin [Cleaved into: Beta-2-microglobulin form pI 5.3], B2M |
UniProt Protein Function: | B2M: Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. Heterodimer of an alpha chain and a beta chain. Beta-2- microglobulin is the beta-chain of major histocompatibility complex class I molecules. Polymers of beta 2-microglobulin can be found in tissues from patients on long-term hemodialysis. Belongs to the beta-2-microglobulin family. |
UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 15q21.1 Cellular Component: Golgi membrane; Golgi apparatus; extracellular space; phagocytic vesicle membrane; focal adhesion; membrane; early endosome membrane; endoplasmic reticulum lumen; cytoplasm; plasma membrane; extracellular region; MHC class I protein complex; external side of plasma membrane Molecular Function:identical protein binding; protein binding Biological Process: response to drug; regulation of immune response; viral reproduction; positive regulation of T cell mediated cytotoxicity; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent; cytokine and chemokine mediated signaling pathway; T cell differentiation in the thymus; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; regulation of defense response to virus by virus; retinal homeostasis; iron ion homeostasis; antigen processing and presentation of peptide antigen via MHC class I; response to cadmium ion; response to molecule of bacterial origin; antigen processing and presentation of exogenous peptide antigen via MHC class I; innate immune response; protein refolding; antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent Disease: Hypoproteinemia, Hypercatabolic |
NCBI Summary: | This gene encodes a serum protein found in association with the major histocompatibility complex (MHC) class I heavy chain on the surface of nearly all nucleated cells. The protein has a predominantly beta-pleated sheet structure that can form amyloid fibrils in some pathological conditions. The encoded antimicrobial protein displays antibacterial activity in amniotic fluid. A mutation in this gene has been shown to result in hypercatabolic hypoproteinemia.[provided by RefSeq, Aug 2014] |
UniProt Code: | P61769 |
NCBI GenInfo Identifier: | 48428791 |
NCBI Gene ID: | 567 |
NCBI Accession: | P61769.1 |
UniProt Related Accession: | P61769 |
Molecular Weight: | |
NCBI Full Name: | Beta-2-microglobulin |
NCBI Synonym Full Names: | beta-2-microglobulin |
NCBI Official Symbol: | B2M |
NCBI Official Synonym Symbols: | IMD43 |
NCBI Protein Information: | beta-2-microglobulin |
UniProt Protein Name: | Beta-2-microglobulin |
Protein Family: | Beta-2-microglobulin |
UniProt Gene Name: | B2M |
UniProt Entry Name: | B2MG_HUMAN |