UniProt Protein Function: | ATPIF1: Endogenous F(1)F(o)-ATPase inhibitor limiting ATP depletion when the mitochondrial membrane potential falls below a threshold and the F(1)F(o)-ATP synthase starts hydrolyzing ATP to pump protons out of the mitochondrial matrix. Homodimer at a pH value below 6.5, inactive homotetramer above. Belongs to the ATPase inhibitor family. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Mitochondrial; Inhibitor Chromosomal Location of Human Ortholog: 1p35.3 Cellular Component: cell surface; mitochondrial proton-transporting ATP synthase complex; mitochondrion Molecular Function:5-formyltetrahydrofolate cyclo-ligase activity; angiostatin binding; ATPase binding; ATPase inhibitor activity; calmodulin binding; enzyme inhibitor activity; protein homodimerization activity Biological Process: angiogenesis; erythrocyte differentiation; folic acid and derivative biosynthetic process; generation of precursor metabolites and energy; heme biosynthetic process; mitochondrial depolarization; negative regulation of ATPase activity; negative regulation of endothelial cell proliferation; negative regulation of hydrolase activity; protein homooligomerization; protein homotetramerization |
NCBI Summary: | This gene encodes a mitochondrial ATPase inhibitor. Alternative splicing occurs at this locus and three transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q9UII2 |
NCBI GenInfo Identifier: | 12585262 |
NCBI Gene ID: | 93974 |
NCBI Accession: | Q9UII2.1 |
UniProt Secondary Accession: | Q9UII2,Q5JXL8, Q6IAQ7, Q9BSL9, |
UniProt Related Accession: | Q9UII2 |
Molecular Weight: | |
NCBI Full Name: | ATPase inhibitor, mitochondrial |
NCBI Synonym Full Names: | ATPase inhibitory factor 1 |
NCBI Official Symbol: | ATPIF1 |
NCBI Official Synonym Symbols: | IP; ATPI; ATPIP |
NCBI Protein Information: | ATPase inhibitor, mitochondrial |
UniProt Protein Name: | ATPase inhibitor, mitochondrial |
UniProt Synonym Protein Names: | Inhibitor of F(1)F(o)-ATPase; IF(1); IF1 |
Protein Family: | ATPase inhibitor |
UniProt Gene Name: | ATPIF1 |
UniProt Entry Name: | ATIF1_HUMAN |