ASIC1 Antibody (PACO05883)
- SKU:
- PACO05883
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | ASIC1 Antibody (PACO05883) |
抗体コード: | PACO05883 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | WB |
推奨される希釈: | WB:1:500-1:2000 |
反応性: | Human, Mouse, Rat |
免疫原: | Synthetic Peptide |
憲法: | Liquid |
ストレージバッファ: | PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol. |
精製方法: | Affinity purification |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
シノニム: | ASIC1 |
UniProt Protein Function: | Isoform 2 and isoform 3 function as proton-gated sodium channels; they are activated by a drop of the extracellular pH and then become rapidly desensitized. The channel generates a biphasic current with a fast inactivating and a slow sustained phase. Has high selectivity for sodium ions and can also transport lithium ions with high efficiency. Isoform 2 can also transport potassium, but with lower efficiency. It is nearly impermeable to the larger rubidium and cesium ions. Isoform 3 can also transport calcium ions. Mediates glutamate-independent Ca2+ entry into neurons upon acidosis. This Ca2+ overloading is toxic for cortical neurons and may be in part responsible for ischemic brain injury. Heteromeric channel assembly seems to modulate channel properties. Functions as a postsynaptic proton receptor that influences intracellular Ca2+ concentration and calmodulin-dependent protein kinase II phosphorylation and thereby the density of dendritic spines. Modulates activity in the circuits underlying innate fear. |
UniProt Protein Details: | |
NCBI Summary: | This gene encodes a member of the acid-sensing ion channel (ASIC) family of proteins, which are part of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. Members of the ASIC family are sensitive to amiloride and function in neurotransmission. The encoded proteins function in learning, pain transduction, touch sensation, and development of memory and fear. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2012] |
UniProt Code: | P78348 |
NCBI GenInfo Identifier: | 296439456 |
NCBI Gene ID: | 41 |
NCBI Accession: | P78348.3 |
UniProt Secondary Accession: | P78348,P78349, Q96CV2, A3KN86, E5KBL7 |
UniProt Related Accession: | P78348 |
Molecular Weight: | 62,700 Da |
NCBI Full Name: | Acid-sensing ion channel 1 |
NCBI Synonym Full Names: | acid sensing ion channel subunit 1 |
NCBI Official Symbol: | ASIC1 |
NCBI Official Synonym Symbols: | ASIC; ACCN2; BNaC2 |
NCBI Protein Information: | acid-sensing ion channel 1 |
UniProt Protein Name: | Acid-sensing ion channel 1 |
UniProt Synonym Protein Names: | Amiloride-sensitive cation channel 2, neuronal; Brain sodium channel 2; BNaC2 |
Protein Family: | Acid-sensing ion channel |
UniProt Gene Name: | ASIC1 |
UniProt Entry Name: | ASIC1_HUMAN |