ASH2L Antibody (PACO15790)
- SKU:
- PACO15790
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | ASH2L Antibody (PACO15790) |
抗体コード: | PACO15790 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, IHC |
推奨される希釈: | ELISA:1:1000-1:5000, IHC:1:50-1:200 |
反応性: | Human, Mouse |
免疫原: | Fusion protein of human ASH2L |
憲法: | Liquid |
ストレージバッファ: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
精製方法: | Antigen affinity purification |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
![]() | The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO15790(ASH2L Antibody) at dilution 1/60, on the right is treated with fusion protein. (Original magnification: x200). |
![]() | The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO15790(ASH2L Antibody) at dilution 1/60, on the right is treated with fusion protein. (Original magnification: x200). |
バックグラウンド: | The human ASH2L gene encodes a 628 amino acid, protein known as ASH2L1, or isoform 1, which contains a nuclear localization signal and PHD finger motif, suggesting that the gene product functions as a transcription regulator. Alternative splicing results in a shorter isoform 2, designated ASH2L2, which is missing the first 94 amino acid, residues found in ASH2L1. Human ASH2L proteins are 60% homologous to Drosophila ash2, which positively regulates expression of certain genes in early development, and contain similar, but not identical, domains, including a zinc finger motif. ASH2L is highly expressed in fetal liver, testis and leukemia cell lines with erythroid and megakaryocytic potential, such as K562, Hel and Dami. |
シノニム: | ash2 (absent, small, or homeotic)-like (Drosophila) |
UniProt Protein Function: | ASH2L: Component of the Set1/Ash2 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3, but not if the neighboring 'Lys-9' residue is already methylated. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. May function as a transcriptional regulator. May play a role in hematopoiesis. Interacts with HCFC1. Core component of several methyltransferase-containing complexes including MLL1/MLL, ASCOM, MLL2/MLL3 and MLL3/MLL4. Each complex is at least composed of ASH2L, RBBP5, DPY30, WDR5, one or more specific histone methyltransferases (MLL, MLL2, MLL3 and MLL4), and the facultative components C16orf53/PA1, C17orf49, CHD8, E2F6, HCFC1, HCFC2, HSP70, INO80C, KDM6A, KANSL1, LAS1L, MAX, MCRS1, MEN1, MGA, KAT8/MOF, NCOA6, PAXIP1/PTIP, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Interacts with DPY30 and RBBP5; the interaction is direct. Component of the SET1 complex, at least composed of the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2L/ASH2, CXXC1/CFP1, HCFC1 and DPY30. Interacts with SETD1A and SETD1B. Ubiquitously expressed. Predominantly expressed in adult heart and testis and fetal lung and liver, with barely detectable expression in adult lung, liver, kidney, prostate, and peripheral leukocytes. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Transcription regulation; Methyltransferase Chromosomal Location of Human Ortholog: 8p11.2 Cellular Component: histone methyltransferase complex; nucleoplasm; nucleus Molecular Function:beta-catenin binding; DNA binding; histone lysine N-methyltransferase activity (H3-K4 specific); histone-lysine N-methyltransferase activity; protein binding Biological Process: histone H3-K4 methylation; positive regulation of cell proliferation; response to DNA damage stimulus; response to estrogen stimulus; transcription from RNA polymerase II promoter |
UniProt Code: | Q9UBL3 |
NCBI GenInfo Identifier: | 32141382 |
NCBI Gene ID: | 9070 |
NCBI Accession: | Q9UBL3.1 |
UniProt Secondary Accession: | Q9UBL3,O60659, O60660, Q96B62, A8K7C3, D3DSW9, |
UniProt Related Accession: | Q9UBL3 |
Molecular Weight: | 60,208 Da |
NCBI Full Name: | Set1/Ash2 histone methyltransferase complex subunit ASH2 |
NCBI Synonym Full Names: | ASH2 like histone lysine methyltransferase complex subunit |
NCBI Official Symbol: | ASH2L |
NCBI Official Synonym Symbols: | ASH2; Bre2; ASH2L1; ASH2L2 |
NCBI Protein Information: | set1/Ash2 histone methyltransferase complex subunit ASH2 |
UniProt Protein Name: | Set1/Ash2 histone methyltransferase complex subunit ASH2 |
UniProt Synonym Protein Names: | ASH2-like protein |
UniProt Gene Name: | ASH2L |
UniProt Entry Name: | ASH2L_HUMAN |
Antibodies |
Anti-ASH2L Antibody (CAB14543) |
Anti-ASH2L Antibody (CAB5392) |
Anti-ASH2L Antibody (CAB17043) |
Anti-ASH2L Antibody (CAB4892) |
ASH2L Antibody (PACO07884) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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