ASGR2 Antibody, HRP conjugated (PACO25089)
- SKU:
- PACO25089
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- HRP
Frequently bought together:
Description
抗体名: | ASGR2 Antibody, HRP conjugated (PACO25089) |
抗体コード: | PACO25089 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Asialoglycoprotein receptor 2 protein (63-286AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | HRP |
バックグラウンド: | Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid, residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface. |
シノニム: | Asialoglycoprotein receptor 2 (ASGP-R 2) (ASGPR 2) (C-type lectin domain family 4 member H2) (Hepatic lectin H2) (HL-2), ASGR2, CLEC4H2 |
UniProt Protein Function: | ASGP-R: cell surface receptor that mediates the endocytosis of plasma glycoproteins in which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. It transports these glycoproteins via a series of membrane vesicles and tubules to an acidic-sorting organelle where the receptor and ligand dissociates. Then the receptor is recycled back to the cell surface. There are four alternatively spliced transcript variants of this gene. |
UniProt Protein Details: | Protein type:Membrane protein, integral; Receptor, misc. Chromosomal Location of Human Ortholog: 17p13.1 Cellular Component: plasma membrane Molecular Function:asialoglycoprotein receptor activity; protein binding Biological Process: cell surface receptor linked signal transduction; protein amino acid N-linked glycosylation via asparagine |
NCBI Summary: | This gene encodes a subunit of the asialoglycoprotein receptor. This receptor is a transmembrane protein that plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of glycoproteins with exposed terminal galactose or N-acetylgalactosamine residues. The asialoglycoprotein receptor may facilitate hepatic infection by multiple viruses including hepatitis B, and is also a target for liver-specific drug delivery. The asialoglycoprotein receptor is a hetero-oligomeric protein composed of major and minor subunits, which are encoded by different genes. The protein encoded by this gene is the less abundant minor subunit. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011] |
UniProt Code: | P07307 |
NCBI GenInfo Identifier: | 218511923 |
NCBI Gene ID: | 433 |
NCBI Accession: | P07307.2 |
UniProt Secondary Accession: | P07307,O00448, Q03969, A6NLV8, A8MT12, D3DTM9, D3DTN0 |
UniProt Related Accession: | P07307 |
Molecular Weight: | 35kDa |
NCBI Full Name: | Asialoglycoprotein receptor 2 |
NCBI Synonym Full Names: | asialoglycoprotein receptor 2 |
NCBI Official Symbol: | ASGR2 |
NCBI Official Synonym Symbols: | HL-2; HBXBP; ASGPR2; ASGP-R2; CLEC4H2 |
NCBI Protein Information: | asialoglycoprotein receptor 2 |
UniProt Protein Name: | Asialoglycoprotein receptor 2 |
UniProt Synonym Protein Names: | C-type lectin domain family 4 member H2; Hepatic lectin H2; HL-2 |
Protein Family: | Asialoglycoprotein receptor |
UniProt Gene Name: | ASGR2 |